The epidermal growth factor receptor (EGFR) signaling plays a key role in the initiation,
progression, growth and metastases of colorectal carcinoma (CRC). Monoclonal antibody …

Background Glypican 1 (GPC1) is a heparan sulphate proteoglycan cell membrane protein.
It is implicated in driving cancers of the breast, brain, pancreas, and prostate; however, its …

Reorganization of cytoskeleton via actin remodeling is a basic step of cell locomotion.
Although cell migration of normal and cancer cells can be stimulated by a variety of intra-and …

We have generated a novel monoclonal antibody (mAb), OCAb9-1, which specifically binds
to various types of cancer cell lines, but not to normal cells. According to the results of …

Background: Hypoxia-inducible factor-1α (HIF-1α) is one of the major tumor-associated
transcription factors modulating numerous tumor properties such as tumor cell metabolism …

Epithelial-to-mesenchymal transition (EMT) is well-known to evoke cancer
invasion/metastasis, leading to a high frequency of mortality in patients with metastatic …

Paxillin (PXN) is a cytoplasmic protein that plays an important role in regulating focal
adhesion, cytoskeletal rearrangements and cell motility. The present study aimed to …

Background: Amino-terminal enhancer of split (AES) has been identified as a tumor and
metastasis suppressor in some cancers including colorectal cancer (CRC), but very little is …

The epithelial cell adhesion molecule (EpCAM) is an integral transmembrane protein that is
frequently overexpressed in embryonic stem cells, tissue progenitors, carcinomas and …

Abstract Background The association of EpCAM expression with the progression of gastric
cancer remains unclear. Here, we investigated the expression of EpCAM in gastric cancer …