The skeleton has the ability to perfectly adapt to external forces of the operating
environment, by altering its morphology and metabolism in order to meet different needs …

The skeleton is subject to dynamic changes throughout life and bone remodeling is
essential for maintenance of bone functionality. The cell populations which predominantly …

Skeletal loading is an important physiological regulator of bone mass. Theoretically,
mechanical forces or administration of drugs that activate bone mechanosensors would be a …

Bone tissue has the capacity to adapt to its functional environment such that its morphology
is “optimized” for the mechanical demand. The adaptive nature of the skeleton poses an …

Bone is a mechano-responsive tissue that adapts to changes in its mechanical environment.
Increases in strain lead to increased bone mass acquisition, whereas decreases in strain …

While it has been long appreciated that biomechanical forces are involved in bone
remodeling and repair, the actual mechanism by which a physical force is translated to the …

Bone remodeling is the continuous turnover of bone matrix and mineral by bone resorption
(activity of osteoclasts) and formation (activity of osteoblasts) in the adult skeleton. The …

Mechanical stimulation has a critical role in the development and maintenance of the
skeleton. This function requires the perception of extracellular stimuli as well as their …

Several in vivo and in vitro studies with different loading regimens showed that mechanical
stimuli have an influence on proliferation and differentiation of bone cells. Prerequisite for …

The skeleton's primary mechanical function is to provide rigid levers for muscles to act
against as they hold the body upright in defiance of gravity. Many bones are exposed to …