Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF3a protein plays a vital
role in viral pathogenesis and coronavirus disease 2019 (COVID-19). Like the spike protein …

The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-
19-related morbidity and mortality, and the high mutability of the virus. One of the major …

The COVID-19 pandemic caused by SARS-CoV-2 has posed unparalleled challenges due
to its rapid transmission, ability to mutate, high mortality and morbidity, and enduring health …

Therapeutic inhibition of critical viral functions is important for curtailing coronavirus disease
2019 (COVID-19). We sought to identify antiviral targets through the genome-wide …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of
deaths, posing a substantial threat to global public health. Viruses evolve different strategies …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome contains nine
open reading frames (ORFs) that encode for accessory proteins which, although …

The open reading frame 8 (orf8) is an accessory protein of SARS-CoV-2. It has 121 amino
acids with two genotypes, orf8L and orf8S. In this study, we overexpressed the orf8L and …

Abstract Background SARS-CoV-2 causes COVID-19 which has a widely diverse disease
profile. The mechanisms underlying its pathogenicity remain unclear. We set out to identify …

The newly emerged betacoronavirus, SARS-CoV-2, causes the COVID-19 pandemic since
December 2019 with more than 35 million laboratory confirmed human infections and over …

In order to understand the transmission and virulence of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), it is necessary to understand the functions of each of the gene …