Mitotic spindles are self-organizing protein machines that harness teams of multiple force
generators to drive chromosome segregation. Kinesins are key members of these force …

Chromosome segregation during cell division requires a bipolar mitotic spindle. Therefore,
how the spindle is formed, maintained, and functions is of fundamental importance for all …

Kinesins are enzymes that use the energy of ATP to perform mechanical work. There are
approximately 14 families of kinesins within the kinesin superfamily. Family classification is …

An outstanding unresolved question is how does the mitotic spindle utilize microtubules and
mitotic motors to coordinate accurate chromosome segregation during mitosis? This process …

Proper chromosome segregation in eukaryotes depends upon the mitotic and meiotic
spindles, which assemble at the time of cell division and then disassemble upon its …

During eukaryote cell division, molecular motors are crucial regulators of microtubule
organization, spindle assembly, chromosome segregation and intracellular transport. The …

Kinesin-5 is required for forming the bipolar spindle during mitosis. Its motor domain, which
contains nucleotide and microtubule binding sites and mechanical elements to generate …

The interplay between microtubules and microtubule-based motors is fundamental to basic
aspects of cellular function, such as the intracellular transport of organelles and alterations …

Mitosis depends on the mitotic spindle, a subcellular protein machine that uses dynamic
microtubules and mitotic motors to assemble itself and to coordinate chromosome …

Kinesin is a superfamily of motor proteins that uses the energy of adenosine triphosphate
hydrolysis to move and generate force along microtubules. A notable exception to this …