Major efforts have been directed at family-based association and case–control studies to
identify the involvement of candidate genes in the major disorders of mental health. What …

Psychiatric disorders such as schizophrenia, bipolar disorder, major depressive disorder,
attention-deficit/hyperactivity disorder and autism spectrum disorder are common and result …

Objective: Knowledge about the genetic basis of psychiatric illness is growing rapidly, and
psychiatrists may be called upon to incorporate this information into clinical practice. The …

The field of psychiatric genetics is highly interdisciplinary, with roots in human genetics,
psychiatry, statistics, and epidemiology. A primary goal in psychiatric genetics is to clarify …

Over the last decade, genome-wide association studies of psychiatric disorders have
identified numerous significant loci. Whereas these studies initially depended on cohorts …

The primary aim of precision medicine is to tailor healthcare more closely to the needs of
individual patients. This requires progress in two areas: the development of more precise …

Over the last years, the decreased costs and enhanced accessibility to large genome-wide
association studies datasets have laid the foundations for the development of polygenic risk …

Objective: Mental disorders are heritable and polygenic, and genome-wide genetic
correlations (rg) have indicated widespread shared genetic risk across multiple disorders …

In this article, we review some of the data that contribute to our understanding of the genetic
architecture of psychiatric disorders. These include results from evolutionary modelling …

Neuropsychiatric disorders are complex conditions with poorly defined neurobiological
bases. In recent years, there have been significant advances in our understanding of the …