The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling

M Ackermann, JC Kamp, C Werlein, CL Walsh… - …, 2022 - thelancet.com
Background COVID-19 is characterized by a heterogeneous clinical presentation, ranging
from mild symptoms to severe courses of disease. 9–20% of hospitalized patients with …

Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19

F D'Agnillo, KA Walters, Y Xiao, ZM Sheng… - Science Translational …, 2021 - science.org
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is characterized by respiratory distress, multiorgan …

Potential mechanisms for lung fibrosis associated with COVID-19 infection

T Parimon, M Espindola, A Marchevsky… - … Journal of Medicine, 2023 - academic.oup.com
Pulmonary fibrosis is a sequelae of Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) infection that currently lacks effective preventative or therapeutic measures …

Healing after COVID-19: are survivors at risk for pulmonary fibrosis?

LT McDonald - … Journal of Physiology-Lung Cellular and …, 2021 - journals.physiology.org
The novel SARS-CoV-2 coronavirus, which is responsible for COVID-19 disease, was first
reported in Wuhan, China, in December of 2019. The virus rapidly spread, and the World …

[HTML][HTML] Progression to lung fibrosis in severe COVID-19 patients: A morphological and transcriptomic study in postmortem samples

B Pérez-Mies, T Caniego-Casas, T Bardi… - Frontiers in …, 2022 - frontiersin.org
The development of lung fibrosis is a major concern in patients recovered from severe
COVID-19 pneumonia. This study aimed to document the evolution of diffuse alveolar …

Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19

M Ackermann, SE Verleden, M Kuehnel… - … England Journal of …, 2020 - Mass Medical Soc
Background Progressive respiratory failure is the primary cause of death in the coronavirus
disease 2019 (Covid-19) pandemic. Despite widespread interest in the pathophysiology of …

Proteomics and metabonomics analyses of Covid-19 complications in patients with pulmonary fibrosis

J Yang, C Chen, W Chen, L Huang, Z Fu, K Ye, L Lv… - Scientific Reports, 2021 - nature.com
Pulmonary fibrosis is a devastating disease, and the pathogenesis of this disease is not
completely clear. Here, the medical records of 85 Covid-19 cases were collected, among …

Pathophysiology of pulmonary fibrosis in the context of COVID-19 and implications for treatment: A narrative review

S Tran, A Ksajikian, J Overbey, P Li, Y Li - Cells, 2022 - mdpi.com
Pulmonary fibrosis (PF) is a feared outcome of many pulmonary diseases which results in a
reduction in lung compliance and capacity. The development of PF is relatively rare, but it …

Molecular and immune signatures, and pathological trajectories of fatal COVID‐19 lungs defined by in situ spatial single‐cell transcriptome analysis

A Das, W Meng, Z Liu, MM Hasib… - Journal of Medical …, 2023 - Wiley Online Library
Despite intensive studies during the last 3 years, the pathology and underlying molecular
mechanism of coronavirus disease 2019 (COVID‐19) remain poorly defined. In this study …

Molecular mechanisms and treatment responses of pulmonary fibrosis in severe COVID-19

EJ Kooistra, K Dahm, AE van Herwaarden… - Respiratory …, 2023 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) patients can develop
pulmonary fibrosis (PF), which is associated with impaired outcome. We assessed specific …