While there are many chip models that simulate the air-tissue interface of the respiratory
system, only a few represent the upper respiratory system. These chips are restricted to …

The function of a well-differentiated nasal epithelium is largely affected by airflow-induced
wall shear stress, yet few in vitro models recapitulate this dynamic condition. Models which …

Organ-on-a-chip microdevices combine microfluidics, MEMS, and biotechnology techniques
to mimic the multicellular architectures, tissue-tissue interfaces, physicochemical …

Human organ-on-a-chip models are powerful tools for preclinical research that can be used
to study the mechanisms of disease and evaluate new targets for therapeutic intervention …

Organ-on-a-chip is a microfluidic cell culture model that replicates key organ-specific
microarchitecture and pathophysiology in vitro. The current methods to fabricate these …

Airway inflammation, a protective response in the human body, can disrupt normal organ
function when chronic, as seen in chronic obstructive pulmonary disease (COPD) and …

Organs-on-chips are microfluidic cell culture devices created using microchip manufacturing
techniques that contain hollow microchannels lined by living cells, which recreate …

Recently, respiratory systems are increasingly threatened by high levels of environmental
pollution. Organ-on-a-chip technology has the advantage of enabling more accurate …

We report a lung-on-a-chip array that mimics the pulmonary parenchymal environment,
including the thin alveolar barrier and the three-dimensional cyclic strain induced by …

The current organ-on-chip platforms used for studying respiratory drug delivery are limited to
the administration of drug solutions and suspensions, lacking the in vivo aerosol drug …