The thyroid TRK-T3 oncogene, produced by a chromosomal translocation, is a chimeric,
constitutively activated version of the NTRK1/NGF receptor and it is able to transform …

The thyroid TRK oncogenes are generated by chromosomal rearrangements juxtaposing
the neurotrophic tyrosine receptor kinase type 1 (NTRK1) tyrosine kinase domain to foreign …

The TRK-T3 oncoprotein, isolated from a human papillary thyroid tumor, arises from the
fusion between the N-terminal domain of the TFG gene and the tyrosine kinase domain of …

Genetic analysis of human papillary thyroid carcinomas (PTC) has revealed unique
chromosomal translocations that form oncogenic fusion proteins and promote thyroid …

The thyroid TRK-T3 oncogene results from the fusion of the tyrosine kinase (TK) domain of
NTRK1 (one of the receptors for the Nerve Growth Factor) on chromosome 1 to sequences …

SHP-1 is a cytoplasmic SH2 domain containing protein-tyrosine phosphatase (PTP)
involved in the negative regulation of multiple signaling pathways in hematopoietic, nervous …

Proto-TRK and proto-RET genes encode receptor type tyrosine kinases. Oncogenic
rearrangements of both proto-oncogenes have been detected with a significant frequency in …

TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC);
they arise from the fusion of the 3′ terminal sequences of the NTRK1/NGF receptor gene …

TRK‐fused gene (TFG) was originally identified in humans as the N‐terminus of an
oncogenic fusion protein TRK‐T3, associated with papillary thyroid carcinoma. An amino …

We have recently reported the frequent activation of the TRK oncogene in human papillary
thyroid carcinoma. In this paper we describe the isolation and characterization of one of the …