UVB radiation is a complete carcinogen able to initiate, promote, and progress keratinocyte cells toward carcinogenesis. Exposure to UVB leads to the propagation of a number of …
JJ Li, Y Cao, MR Young… - … : Published in cooperation …, 2000 - Wiley Online Library
Neoplastically transformed mouse and human keratinocytes elevate transactivation of both activator protein 1 (AP‐1) and nuclear factor κB (NFκB) transcription factors. The present …
SJ Cooper, GT Bowden - Current cancer drug targets, 2007 - ingentaconnect.com
Prolonged and repeated exposure of the skin to ultraviolet light (UV) leads not only to aging of the skin but also increases the incidence of non-melanoma skin cancer (NMSC). Damage …
AP-1 transactivation appears to be required for mouse JB6 cell neoplastic transformation induced by the tumor promoter TPA or epidermal growth factor (EGF). Exposure to AP-1 …
Z Dong, HC Crawford, V Lavrovsky… - … in cooperation with …, 1997 - Wiley Online Library
We previously reported that induced activator protein‐1 (AP‐1) transcriptional activity appears to be required for tumor promoter–induced transformation in mouse epidermal JB6 …
M Garmyn, H Degreef - Journal of Photochemistry and Photobiology B …, 1997 - Elsevier
Irradiation of human keratinocytes with UVB results in the early induction of proto- oncogenes c-fos and c-jun, members of the AP-1 protein family of transcription factors. To …
W Chen, GT Bowden - … in cooperation with the University of …, 2000 - Wiley Online Library
The effects of p38 mitogen‐activated protein kinases on ultraviolet (UV) B irradiation– induced activator protein 1 (AP‐1) activation were studied in a human keratinocyte cell line …
DA Lewis, DF Spandau - Journal of investigative dermatology, 2008 - Elsevier
To manage the frequent exposure to carcinogenic UVB wavelengths found in sunlight, keratinocytes have extensive protective measures to handle UVB-induced DNA damage …
AL Silvers, MA Bachelor, GT Bowden - Neoplasia, 2003 - Elsevier
To further delineate ultraviolet A (UVA) signaling pathways in the human keratinocyte cell line HaCaT, we examined the potential role of mitogen-activated protein kinases (MAPKs) in …