Differential inhibition of UVB‐induced AP‐1 and NF‐κB transactivation by components of the jun bZIP domain
S Cooper, J Ranger‐Moore… - … in cooperation with the …, 2005 - Wiley Online Library
Potential targets for chemoprevention of nonmelanoma skin cancer include UV‐induced
nuclear factor κB (NF‐κB) and activator protein‐1 (AP‐1) activation in keratinocytes …
nuclear factor κB (NF‐κB) and activator protein‐1 (AP‐1) activation in keratinocytes …
Expression of Dominant Negative c-jun Inhibits Ultraviolet B-Induced Squamous Cell Carcinoma Number and Size in an SKH-1 Hairless Mouse Model
SJ Cooper, J MacGowan, J Ranger-Moore… - Molecular cancer …, 2003 - AACR
UVB radiation is a complete carcinogen able to initiate, promote, and progress keratinocyte
cells toward carcinogenesis. Exposure to UVB leads to the propagation of a number of …
cells toward carcinogenesis. Exposure to UVB leads to the propagation of a number of …
Induced expression of dominant‐negative c‐jun downregulates NFκB and AP‐1 target genes and suppresses tumor phenotype in human keratinocytes
Neoplastically transformed mouse and human keratinocytes elevate transactivation of both
activator protein 1 (AP‐1) and nuclear factor κB (NFκB) transcription factors. The present …
activator protein 1 (AP‐1) and nuclear factor κB (NFκB) transcription factors. The present …
Ultraviolet B regulation of transcription factor families: Roles of nuclear factor-kappa B (NF-κB) and activator protein-1 (AP-1) in UVB-induced skin carcinogenesis
SJ Cooper, GT Bowden - Current cancer drug targets, 2007 - ingentaconnect.com
Prolonged and repeated exposure of the skin to ultraviolet light (UV) leads not only to aging
of the skin but also increases the incidence of non-melanoma skin cancer (NMSC). Damage …
of the skin but also increases the incidence of non-melanoma skin cancer (NMSC). Damage …
Expression of dominant negative Jun inhibits elevated AP-1 and NF-κB transactivation and suppresses anchorage independent growth of HPV immortalized human …
JJ Li, JS Rhim, R Schlegel, KH Vousden, NH Colburn - Oncogene, 1998 - nature.com
AP-1 transactivation appears to be required for mouse JB6 cell neoplastic transformation
induced by the tumor promoter TPA or epidermal growth factor (EGF). Exposure to AP-1 …
induced by the tumor promoter TPA or epidermal growth factor (EGF). Exposure to AP-1 …
A dominant negative mutant of jun blocking 12‐O‐tetradecanoylphorbol‐13‐acetate–induced invasion in mouse keratinocytes
Z Dong, HC Crawford, V Lavrovsky… - … in cooperation with …, 1997 - Wiley Online Library
We previously reported that induced activator protein‐1 (AP‐1) transcriptional activity
appears to be required for tumor promoter–induced transformation in mouse epidermal JB6 …
appears to be required for tumor promoter–induced transformation in mouse epidermal JB6 …
Suppression of UVB-induced c-fos and c-jun expression in human keratinocytes by N-acetylcysteine
M Garmyn, H Degreef - Journal of Photochemistry and Photobiology B …, 1997 - Elsevier
Irradiation of human keratinocytes with UVB results in the early induction of proto-
oncogenes c-fos and c-jun, members of the AP-1 protein family of transcription factors. To …
oncogenes c-fos and c-jun, members of the AP-1 protein family of transcription factors. To …
Role of p38 mitogen‐activated protein kinases in ultraviolet‐B irradiation–induced activator protein 1 activation in human keratinocytes
W Chen, GT Bowden - … in cooperation with the University of …, 2000 - Wiley Online Library
The effects of p38 mitogen‐activated protein kinases on ultraviolet (UV) B irradiation–
induced activator protein 1 (AP‐1) activation were studied in a human keratinocyte cell line …
induced activator protein 1 (AP‐1) activation were studied in a human keratinocyte cell line …
[HTML][HTML] UVB-induced activation of NF-κB is regulated by the IGF-1R and dependent on p38 MAPK
DA Lewis, DF Spandau - Journal of investigative dermatology, 2008 - Elsevier
To manage the frequent exposure to carcinogenic UVB wavelengths found in sunlight,
keratinocytes have extensive protective measures to handle UVB-induced DNA damage …
keratinocytes have extensive protective measures to handle UVB-induced DNA damage …
The role of JNK and p38 MAPK activities in UVA-induced signaling pathways leading to AP-1 activation and c-Fos expression
AL Silvers, MA Bachelor, GT Bowden - Neoplasia, 2003 - Elsevier
To further delineate ultraviolet A (UVA) signaling pathways in the human keratinocyte cell
line HaCaT, we examined the potential role of mitogen-activated protein kinases (MAPKs) in …
line HaCaT, we examined the potential role of mitogen-activated protein kinases (MAPKs) in …