Histone posttranslational modifications and chromatin dynamics are inextricably linked to
eukaryotic gene expression. Among the many modifications that have been characterized …

The impact of histone acetylation on transcription was revealed over 50 years ago by Allfrey
and colleagues. However, it took decades for an understanding of the fine mechanism by …

We have used a purified recombinant chromatin assembly system, including ACF (Acf-1+
ISWI) and NAP-1, to examine the role of histone acetylation in ATP-dependent chromatin …

Eukaryotic DNA is packaged into a nucleoprotein structure known as chromatin, which is
comprised of DNA, histones, and nonhistone proteins. Chromatin structure is highly …

Posttranslational acetylation of the conserved core histone N-terminal tail domains is linked
to gene activation, but the molecular mechanisms involved are not known. In an earlier study …

The packaging of DNA into chromatin is an important regulator of transcription. This
regulation may operate either by short-term switching of the transcription of specific genes or …

In eukaryotes, DNA is assembled with histones to form nucleosomes, the basic subunit of
chromatin structure. The wrapping of DNA around histone octamers to form nucleosomal …

Post-translational modifications of proteins have emerged as a major mechanism for
regulating gene expression. However, our understanding of how histone modifications …

The organization of eukaryotic chromatin has a major impact on all nuclear processes
involving DNA substrates. Gene expression is affected by the positioning of individual …

Although the nucleosome in its role as the fundamental structural unit of eukaryotic
chromatin has been with us for many years, mysteries remain. Prominent among them is the …