Ultrasound-triggered drug targeting of tumors in vitro and in vivo

NY Rapoport, DA Christensen, HD Fain, L Barrows… - Ultrasonics, 2004 - Elsevier
The new modality of drug targeting of tumors that we are currently developing is based on
drug encapsulation in polymeric micelles, followed by the localized release at the tumor site …

Controlled and targeted tumor chemotherapy by micellar-encapsulated drug and ultrasound

ZG Gao, HD Fain, N Rapoport - Journal of Controlled Release, 2005 - Elsevier
The results of a comprehensive in vivo study of a novel tumor-targeting modality are
reported. The technique utilized in this study is based on the encapsulation of the …

Combined cancer therapy by micellar-encapsulated drugs and ultrasound

N Rapoport - Nanotechnology for cancer therapy, 2006 - taylorfrancis.com
Chemotherapy is often complicated by toxic side effects of anti-cancer drugs. This chapter
reviews the state of the art in drug targeting to tumors using polymeric micelles as drug …

[PDF][PDF] Ultrasonic drug delivery in Oncology

I Udroiu - J. BUON, 2015 - jbuon.com
Ultrasound-assisted drug delivery is an emerging technique that has the advantage of being
non-invasive, efficiently and specifically targeted and controllable. While systemic drugs …

Drug delivery in polymeric micelles: from in vitro to in vivo

N Rapoport, WG Pitt, H Sun, JL Nelson - Journal of Controlled Release, 2003 - Elsevier
A new drug delivery modality was developed based on drug encapsulation in polymeric
micelles followed by a controlled release at the tumor site triggered by ultrasound focused …

The use of ultrasound and micelles in cancer treatment

GA Husseini, WG Pitt - Journal of Nanoscience and …, 2008 - ingentaconnect.com
The high toxicity of potent chemotherapeutic drugs like Doxorubicin (Dox) limits the
therapeutic window in which they can be applied. This window can be expanded by …

Ultrasonically activated chemotherapeutic drug delivery in a rat model

JL Nelson, BL Roeder, JC Carmen, F Roloff, WG Pitt - Cancer research, 2002 - AACR
Systemic delivery of anticancer agents is accompanied by many unwanted side effects that
can be mitigated by encapsulation of antineoplastic agents. However, encapsulation …

Ultrasound-mediated micellar drug delivery

N Rapoport - International Journal of Hyperthermia, 2012 - Taylor & Francis
During the last decade, nanomedicine has emerged as a new field of medicine that utilises
nanoscale materials for delivery of drugs, genes and imaging agents. The efficiency of drug …

[HTML][HTML] Ultrasonic enhancement of drug penetration in solid tumors

CY Lai, BZ Fite, KW Ferrara - Frontiers in Oncology, 2013 - frontiersin.org
Increasing the penetration of drugs within solid tumors can be accomplished through
multiple ultrasound-mediated mechanisms. The application of ultrasound can directly …

Ultrasound-mediated drug delivery in cancer therapy: A review

NM Al Sawaftah, GA Husseini - Journal of Nanoscience and …, 2020 - ingentaconnect.com
The use of ultrasound as a medical diagnostic tool began in the 1940s. Ever since, the
medical applications of ultrasound have included imaging, tumor ablation, and lithotripsy; …