In both clinical care and research, genetics and genomics are no longer solely in the domain
of geneticists and basic science researchers. On the clinical side, there is expanding …

The kidney is subject to a wide range of abnormalities, many of which have a significant
hereditable component. Next generation sequencing is increasingly bringing the genetic …

Key differences exist between clinical and research genomics. As genomic testing is
adopted in nephrology clinical care, we propose focusing on clinical genomics approaches …

Technologies such as next-generation sequencing and chromosomal microarray have
advanced the understanding of the molecular pathogenesis of a variety of renal disorders …

Genetic testing may have broad benefits for patients and their families. Knowing the precise
molecular etiology of disease can help clinicians determine the exact therapeutic course …

Technical advances in genome sequencing and association studies have yielded critical
insights into the genetic architecture of kidney diseases. Here, I summarize four key studies …

It has long been known that inherited kidney disor-ders such as polycystic kidney disease
(PKD) can be caused by mutations in a single gene. These disorders are termed monogenic …

The cohort was 57% white, 16% black, 8% Hispanic, 2% Asian, and 15% other. The average
age was 30 years but ranged from infancy to later adulthood, and only a minority had known …

Clinical genetics is increasingly recognized as an important area within nephrology care.
Clinicians require awareness of genetic kidney disease to recognize clinical phenotypes …

Next-generation sequencing has dramatically decreased the cost of gene sequencing,
facilitating the simultaneous analysis of multiple genes at the same time; obtaining a genetic …