Therapeutic approaches for SARS-CoV-2 infection

A Gupta, A Pradhan, VK Maurya, S Kumar, A Theengh… - Methods, 2021 - Elsevier
Therapeutic approaches to COVID-19 treatment require appropriate inhibitors to target
crucial proteins of SARS-CoV-2 replication machinery. It's been approximately 12 months …

COVID-19 drug discovery and treatment options

JFW Chan, S Yuan, H Chu, S Sridhar… - Nature Reviews …, 2024 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused substantial morbidity and …

Promising repurposed antiviral molecules to combat SARS-CoV-2: A review

Y Ratan, A Rajput, V Jain, DK Mishra… - Current …, 2023 - ingentaconnect.com
COVID-19, an extremely transmissible and pathogenic viral disease, triggered a global
pandemic that claimed lives worldwide. To date, there is no clear and fully effective …

Accelerated preclinical paths to support rapid development of COVID-19 therapeutics

JA Grobler, AS Anderson, P Fernandes, MS Diamond… - Cell Host & Microbe, 2020 - cell.com
When SARS-CoV-2 emerged at the end of 2019, no approved therapeutics or vaccines were
available. An urgent need for countermeasures during this crisis challenges the current …

Old drugs for a new virus: repurposed approaches for combating COVID-19

S Saul, S Einav - ACS infectious diseases, 2020 - ACS Publications
There is a large global unmet need for effective countermeasures to combat severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus …

Tackling SARS-CoV-2: proposed targets and repurposed drugs

S Joshi, M Joshi, MS Degani - Future medicinal chemistry, 2020 - Taylor & Francis
The SARS-CoV-2 pandemic, declared as a global health emergency by the WHO in
February 2020, has currently infected more than 6 million people with fatalities near 371,000 …

COVID-19 therapeutics: Challenges and directions for the future

PC Robinson, DFL Liew, HL Tanner… - Proceedings of the …, 2022 - National Acad Sciences
The emergence of SARS-CoV-2 triggering the COVID-19 pandemic ranks as arguably the
greatest medical emergency of the last century. COVID-19 has highlighted health disparities …

A painful lesson from the COVID-19 pandemic: the need for broad-spectrum, host-directed antivirals

VC Chitalia, AH Munawar - Journal of translational medicine, 2020 - Springer
While the COVID-19 pandemic has spurred intense research and collaborative discovery
worldwide, the development of a safe, effective, and targeted antiviral from the ground up is …

An Update on SARS-CoV-2 Clinical Trial Results—What We Can Learn for the Next Pandemic

BY Arman, J Brun, ML Hill, N Zitzmann… - International Journal of …, 2023 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic has claimed over 7 million lives
worldwide, providing a stark reminder of the importance of pandemic preparedness. Due to …

Identification and development of therapeutics for COVID-19

HM Rando, N Wellhausen, S Ghosh, AJ Lee… - Msystems, 2021 - Am Soc Microbiol
After emerging in China in late 2019, the novel coronavirus severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) spread worldwide, and as of mid-2021, it remains a …