[HTML][HTML] RNA structure and splicing regulation

FE Baralle, RN Singh, S Stamm - Biochimica et biophysica acta …, 2019 - ncbi.nlm.nih.gov
The process of pre-mRNA splicing is fundamental to gene regulation in eukaryotes. Specific
RNA sequences called introns, which do not code for amino acids, are removed during …

The biochemistry of pre-mRNA splicing

AI Lamond, RG Landes Company, A Krämer - Pre-mRNA processing, 1995 - Springer
The primary transcripts of most nuclear protein-coding genes of eu-karyotes are interrupted
by intervening sequences (or introns) that are removed from the pre-mRNA in a process …

Role of RNA structure in regulating pre-mRNA splicing

MB Warf, JA Berglund - Trends in biochemical sciences, 2010 - cell.com
Pre-mRNA splicing involves removing non-coding introns from RNA transcripts. It is carried
out by the spliceosome, along with other auxiliary factors. In general, research in splicing …

Mechanisms of regulated pre-mRNA splicing

AI Lamond, RG Landes Company, J Valcárcel… - Pre-mRNA …, 1995 - Springer
Most messenger RNAs in higher eukaryotes are transcribed as precursors containing
intervening sequences (introns). Introns are removed by a sophisticated processing …

Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects

ME Rogalska, C Vivori, J Valcárcel - Nature Reviews Genetics, 2023 - nature.com
The removal of introns from mRNA precursors and its regulation by alternative splicing are
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …

The mammalian pre-mRNA splicing apparatus

AI Lamond, S Barabino, BJ Blencowe - Nucleic Acids and Molecular …, 1990 - Springer
The excision of introns from nuclear mRNA precursors (pre-mRNA) is a fundamental step in
the biogenesis of most mRNAs in eukaryotic cells and occurs prior to the transport of newly …

Mechanisms and regulation of spliceosome‐mediated pre‐mRNA splicing in Saccharomyces cerevisiae

KA Senn, AA Hoskins - Wiley Interdisciplinary Reviews: RNA, 2024 - Wiley Online Library
Pre‐mRNA splicing, the removal of introns and ligation of flanking exons, is a crucial step in
eukaryotic gene expression. The spliceosome, a macromolecular complex made up of five …

Biochemistry and regulation of pre-mRNA splicing

MD Adams, DZ Rudner, DC Rio - Current opinion in cell biology, 1996 - Elsevier
During the past year, significant advances have been made in the field of pre-mRNA
splicing. It is now clear that members of the serine—arginine-rich protein family are key …

Yeast pre-mRNA splicing: methods, mechanisms, and machinery

SW Stevens, J Abelson - Methods in enzymology, 2002 - Elsevier
Publisher Summary This chapter discusses the process of pre-mRNA splicing in yeasts. The
chapter outlines the history of pre-mRNA splicing. The genes for dozens of protein factors …

More than a messenger: Alternative splicing as a therapeutic target

AJ Black, JR Gamarra, J Giudice - Biochimica et Biophysica Acta (BBA) …, 2019 - Elsevier
Alternative splicing of pre-mRNA is an essential post-and co-transcriptional mechanism of
gene expression regulation that produces multiple mature mRNA transcripts from a single …