Circular RNAs in cardiovascular diseases

X Mei, SY Chen - Pharmacology & therapeutics, 2022 - Elsevier
In eukaryotes, precursor mRNAs (pre-mRNAs) produce a unique class of biologically active
molecules namely circular RNAs (circRNAs) with a covalently closed-loop structure via back …

Role of circular RNAs in the pathogenesis of cardiovascular disease

B Li, Y Li, L Hu, Y Liu, Q Zhou, M Wang, Y An… - Journal of cardiovascular …, 2020 - Springer
Circular RNAs (circRNAs) are single-strand covalently closed circular noncoding RNAs that
are endogenous transcripts generated from linear precursor mRNA through a backsplicing …

Circular RNAs open a new chapter in cardiovascular biology

S Aufiero, YJ Reckman, YM Pinto… - Nature Reviews …, 2019 - nature.com
Circular RNAs (circRNAs) are emerging as a new class of non-coding RNA molecules. This
unusual class of RNA species is generated by a back-splicing event of one or two exons …

Circular RNAs: functions and clinical significance in cardiovascular disease

L Zhang, Y Zhang, Y Wang, Y Zhao… - Frontiers in cell and …, 2020 - frontiersin.org
Cardiovascular disease (CVD) causes high morbidity and mortality worldwide. Accumulating
research has indicated the possible roles played by circular RNAs (circRNAs) in the …

Circular RNAs: a novel class of functional RNA molecules with a therapeutic perspective

L Santer, C Bär, T Thum - Molecular Therapy, 2019 - cell.com
Circular RNAs (circRNAs) are a subclass of non-coding RNAs that lack free 3′ and 5′
ends and, thus, exist as continuous loop RNAs. Such circular transcripts have been …

The emerging landscape of circular RNA in cardiovascular diseases

M Zhou, JM Yang, X Xiong - Journal of Molecular and Cellular Cardiology, 2018 - Elsevier
Circular RNAs (circRNAs), a large novel type of endogenous transcripts, have become a
new research hotspot in the field of RNA biology. CircRNAs are mainly generated from …

circRNA is a potential target for cardiovascular diseases treatment

J Ju, Y Song, X Chen, T Wang, C Liu… - Molecular and Cellular …, 2022 - Springer
Circular RNAs (circRNAs), a novel class of endogenous noncoding RNA, are characterized
by their covalently closed-loop structures without a 5′ cap or a 3′ poly (A) tail. With the …

Circular RNAs in cardiovascular disease: an overview

X Fan, X Weng, Y Zhao, W Chen… - BioMed research …, 2017 - Wiley Online Library
Circular RNA (circRNA), a novel type of endogenous noncoding RNA (ncRNA), has become
a research hotspot in recent years. CircRNAs are abundant and stably exist in creatures …

Circular RNAs in cardiovascular diseases: regulation and therapeutic applications

L Wang, G Xu, M Spanos, G Li, Z Lei, JPG Sluijter… - Research, 2023 - spj.science.org
Cardiovascular disease is one of the leading causes of mortality worldwide. Recent studies
have shown that circular RNAs (circRNAs) have emerged as important players in the …

The function and therapeutic potential of circular RNA in cardiovascular diseases

K Wang, XQ Gao, T Wang, LY Zhou - Cardiovascular Drugs and Therapy, 2021 - Springer
Circular RNA (circRNA) has a closed-loop structure, and its 3'and 5'ends are directly
covalently connected by reverse splicing, which is more stable than linear RNA. CircRNAs …