Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis
We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung
disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 …
disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 …
[HTML][HTML] Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a lethal interstitial lung disease characterized by airway
remodeling, inflammation, alveolar destruction, and fibrosis. We utilized single-cell RNA …
remodeling, inflammation, alveolar destruction, and fibrosis. We utilized single-cell RNA …
Cloning a profibrotic stem cell variant in idiopathic pulmonary fibrosis
S Wang, W Rao, A Hoffman, J Lin, J Li, T Lin… - Science translational …, 2023 - science.org
Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible, and rapidly fatal interstitial
lung disease marked by the replacement of lung alveoli with dense fibrotic matrices …
lung disease marked by the replacement of lung alveoli with dense fibrotic matrices …
Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis
Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …
Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis
PA Reyfman, JM Walter, N Joshi… - American journal of …, 2019 - atsjournals.org
Rationale: The contributions of diverse cell populations in the human lung to pulmonary
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal …
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal …
Defining the activated fibroblast population in lung fibrosis using single-cell sequencing
R Peyser, S MacDonnell, Y Gao, L Cheng… - American journal of …, 2019 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disorder driven by
unrelenting extracellular matrix deposition. Fibroblasts are recognized as the central …
unrelenting extracellular matrix deposition. Fibroblasts are recognized as the central …
Multiple fibroblast subtypes contribute to matrix deposition in pulmonary fibrosis
Progressive pulmonary fibrosis results from a dysfunctional tissue repair response and is
characterized by fibroblast proliferation, activation, and invasion and extracellular matrix …
characterized by fibroblast proliferation, activation, and invasion and extracellular matrix …
Disparate interferon signaling and shared aberrant basaloid cells in single-cell profiling of idiopathic pulmonary fibrosis and systemic sclerosis-associated interstitial …
E Valenzi, T Tabib, A Papazoglou, J Sembrat… - Frontiers in …, 2021 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung
disease (SSc-ILD) differ in the predominant demographics and identified genetic risk alleles …
disease (SSc-ILD) differ in the predominant demographics and identified genetic risk alleles …
Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage
Tissue fibrosis is a major cause of mortality that results from the deposition of matrix proteins
by an activated mesenchyme. Macrophages accumulate in fibrosis, but the role of specific …
by an activated mesenchyme. Macrophages accumulate in fibrosis, but the role of specific …
Transcriptomic evidence of immune activation in macroscopically normal-appearing and scarred lung tissues in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease manifested by overtly scarred
peripheral and basilar regions and more normal-appearing central lung areas. Lung tissues …
peripheral and basilar regions and more normal-appearing central lung areas. Lung tissues …
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