Protective role of ACE2 and its downregulation in SARS-CoV-2 infection leading to Macrophage Activation Syndrome: Therapeutic implications

N Banu, SS Panikar, LR Leal, AR Leal - Life sciences, 2020 - Elsevier
In light of the outbreak of the 2019 novel coronavirus disease (COVID-19), the international
scientific community has joined forces to develop effective treatment strategies. The …

Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infection

X Gao, S Zhang, J Gou, Y Wen, L Fan, J Zhou, G Zhou… - Journal of Infection, 2022 - Elsevier
The ongoing global pandemic of Coronavirus disease 2019 (COVID-19) poses a serious
threat to human health, with patients reportedly suffering from thrombus, vascular injury and …

Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor

Y Li, W Zhou, L Yang, R You - Pharmacological research, 2020 - Elsevier
The renin-angiotensin system (RAS) is crucial for the physiology and pathology of all the
organs. Angiotensin-converting enzyme 2 (ACE2) maintains the homeostasis of RAS as a …

Searching therapeutic strategy of new coronavirus pneumonia from angiotensin-converting enzyme 2: the target of COVID-19 and SARS-CoV

S Li, Z Tang, Z Li, X Liu - European Journal of Clinical Microbiology & …, 2020 - Springer
Since December 2019, the infection of the new coronavirus (COVID-19) caused an outbreak
of new coronavirus pneumonia in Wuhan, China, and caused great public concern. Both …

Potential role of ACE2 in coronavirus disease 2019 (COVID-19) prevention and management

M Liu, T Wang, Y Zhou, Y Zhao, Y Zhang… - Journal of translational …, 2020 - degruyter.com
COVID-19 is the current public health threat all over the world. Unfortunately, there is no
specific prevention and treatment strategy for this disease. We aim to explore the potential …

The renin-angiotensin system: a key role in SARS-CoV-2-induced COVID-19

G El-Arif, A Farhat, S Khazaal, C Annweiler, H Kovacic… - Molecules, 2021 - mdpi.com
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative
agent of coronavirus disease 2019 (COVID-19), was first identified in Eastern Asia (Wuhan …

[HTML][HTML] Understanding on the possible routes for SARS CoV-2 invasion via ACE2 in the host linked with multiple organs damage

N Kirtipal, S Kumar, SK Dubey, VD Dwivedi… - Infection, Genetics and …, 2022 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), accountable for causing
the coronavirus diseases 2019 (COVID-19), is already declared as a pandemic disease …

Coronavirus disease 2019 (COVID-19) and the renin-angiotensin system: A closer look at angiotensin-converting enzyme 2 (ACE2)

AE Zemlin, OJ Wiese - Annals of clinical biochemistry, 2020 - journals.sagepub.com
Since the first cases of atypical pneumonia linked to the Huanan Seafood Wholesale Market
in Wuhan, China, were described in late December 2019, the global landscape has …

Angiotensin-converting enzyme 2 and COVID-19: patients, comorbidities, and therapies

G Pathangey, PP Fadadu… - American Journal of …, 2021 - journals.physiology.org
On March 11, 2020, the World Health Organization declared coronavirus disease 2019
(COVID-19) a pandemic, and the reality of the situation has finally caught up to the …

Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches

Y Jin, W Ji, H Yang, S Chen, W Zhang… - Signal transduction and …, 2020 - nature.com
On 12 March 2020, the outbreak of coronavirus disease 2019 (COVID-19) was declared a
pandemic by the World Health Organization. As of 4 August 2020, more than 18 million …