[HTML][HTML] ACE2 down-regulation may act as a transient molecular disease causing RAAS dysregulation and tissue damage in the microcirculatory environment among …

SG Ramos, BA da Cruz Rattis, G Ottaviani… - The American journal of …, 2021 - Elsevier
Abstract SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the etiological
agent of COVID-19 (coronavirus disease 2019) and the cause of the current pandemic …

SARS-CoV-2 infections and ACE2: clinical outcomes linked with increased morbidity and mortality in individuals with diabetes

AG Obukhov, BR Stevens, R Prasad, S Li Calzi… - Diabetes, 2020 - Am Diabetes Assoc
Individuals with diabetes suffering from coronavirus disease 2019 (COVID-19) exhibit
increased morbidity and mortality compared with individuals without diabetes. In this …

ACE2 and COVID-19 and the resulting ARDS

X Zhang, S Li, S Niu - Postgraduate medical journal, 2020 - academic.oup.com
This article reviews the correlation between ACE2 and COVID-19 and the resulting acute
respiratory distress syndrome (ARDS). ACE2 is a crucial component of the renin-angiotensin …

Expressions and significances of the angiotensin-converting enzyme 2 gene, the receptor of SARS-CoV-2 for COVID-19

J Fu, B Zhou, L Zhang, KS Balaji, C Wei, X Liu… - Molecular biology …, 2020 - Springer
The ACE2 gene is a receptor of SARS-CoV-2 (severe acute respiratory syndrome
coronavirus 2) for COVID-19 (coronavirus disease 2019). To analyze the expression profiles …

A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor

M Oz, DE Lorke, N Kabbani - Pharmacology & therapeutics, 2021 - Elsevier
The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has
prompted scientists to address an urgent need for defining mechanisms of disease …

[HTML][HTML] Endothelial dysfunction in COVID-19: Current findings and therapeutic implications

MP Nägele, B Haubner, FC Tanner, F Ruschitzka… - Atherosclerosis, 2020 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) increases the risk of several non-pulmonary
complications such as acute myocardial injury, renal failure or thromboembolic events. A …

Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention

E Shirbhate, J Pandey, VK Patel, M Kamal… - Pharmacological …, 2021 - Springer
Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with
hypertension, renin–angiotensin–aldosterone system pathway, and other cardiovascular …

[HTML][HTML] Induced dysregulation of ACE2 by SARS-CoV-2 plays a key role in COVID-19 severity

ME Mehrabadi, R Hemmati, A Tashakor… - Biomedicine & …, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the cause of COVID-19, is
reported to increase the rate of mortality worldwide. COVID-19 is associated with acute …

Covid-19: the renin–angiotensin system imbalance hypothesis

K Lanza, LG Perez, LB Costa, TM Cordeiro… - Clinical …, 2020 - portlandpress.com
The emergency of SARS-CoV-2 in China started a novel challenge to the scientific
community. As the virus turns pandemic, scientists try to map the cellular mechanisms and …

ACE/ACE2 ratio: a key also in 2019 coronavirus disease (Covid-19)?

P Pagliaro, C Penna - Frontiers in medicine, 2020 - frontiersin.org
Angiotensin-converting enzyme 2 (ACE2) is an aminopeptidase that converts Angiotensin
(Ang) II into Ang (1-7). Coronavirus uses ACE2 as a cellular receptor to invade target cells …