Coupling biomechanics to a cellular level model: an approach to patient-specific image driven multi-scale and multi-physics tumor simulation

CP May, E Kolokotroni, GS Stamatakos… - Progress in biophysics …, 2011 - Elsevier
Modeling of tumor growth has been performed according to various approaches addressing
different biocomplexity levels and spatiotemporal scales. Mathematical treatments range …

Non-diffeomorphic registration of brain tumor images by simulating tissue loss and tumor growth

EI Zacharaki, CS Hogea, D Shen, G Biros… - Neuroimage, 2009 - Elsevier
Although a variety of diffeomorphic deformable registration methods exist in the literature,
application of these methods in the presence of space-occupying lesions is not …

An image-driven parameter estimation problem for a reaction–diffusion glioma growth model with mass effects

C Hogea, C Davatzikos, G Biros - Journal of mathematical biology, 2008 - Springer
We present a framework for modeling gliomas growth and their mechanical impact on the
surrounding brain tissue (the so-called, mass-effect). We employ an Eulerian continuum …

A biomechanical model of soft tissue deformation, with applications to non-rigid registration of brain images with tumor pathology

SK Kyriacou, C Davatzikos - … Conference Cambridge, MA, USA, October 11 …, 1998 - Springer
The finite element method is applied to the biomechanics of brain tissue deformation.
Emphasis is given to the deformations induced by the growth of tumors, and to the …

Towards computing brain deformations for diagnosis, prognosis and neurosurgical simulation

K Miller, Z Taylor, WL Nowinski - Journal of Mechanics in Medicine …, 2005 - World Scientific
The objective of our research is to create a system computing brain deformations. We have
in view both clinical and training applications, such as" brain shift" calculation, prognosis …

Encoding probabilistic brain atlases using Bayesian inference

K Van Leemput - IEEE Transactions on Medical Imaging, 2008 - ieeexplore.ieee.org
This paper addresses the problem of creating probabilistic brain atlases from manually
labeled training data. Probabilistic atlases are typically constructed by counting the relative …

Finite element modeling of brain tumor mass-effect from 3D medical images

A Mohamed, C Davatzikos - … Conference, Palm Springs, CA, USA, October …, 2005 - Springer
Motivated by the need for methods to aid the deformable registration of brain tumor images,
we present a three-dimensional (3D) mechanical model for simulating large non-linear …

Brain atlas deformation in the presence of large space-occupying tumors

BM Dawant, SL Hartmann, S Gadamsetty - Medical Image Computing and …, 1999 - Springer
Brain atlases contain a wealth of information that could be used for radiation therapy or
neurosurgical planning. So far, however, when large space occupying tumors and lesions …

Combining generative models for multifocal glioma segmentation and registration

D Kwon, RT Shinohara, H Akbari… - Medical Image Computing …, 2014 - Springer
In this paper, we propose a new method for simultaneously segmenting brain scans of
glioma patients and registering these scans to a normal atlas. Performing joint segmentation …

Atlas-based automatic segmentation of MR images: validation study on the brainstem in radiotherapy context

PY Bondiau, G Malandain, S Chanalet… - International Journal of …, 2005 - Elsevier
PURPOSE: Brain tumor radiotherapy requires the volume measurements and the
localization of several individual brain structures. Any tool that can assist the physician to …