Genome-wide association study of cannabis dependence severity, novel risk variants, and shared genetic risks
Importance Cannabis dependence (CAD) is a serious problem worldwide and is of growing
importance in the United States because cannabis is increasingly available legally …
importance in the United States because cannabis is increasingly available legally …
Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans
BACKGROUND: A genetic contribution to cannabis dependence (CaD) has been
established but susceptibility genes for CaD remain largely unknown. METHODS: We …
established but susceptibility genes for CaD remain largely unknown. METHODS: We …
[HTML][HTML] A large-scale genome-wide association study meta-analysis of cannabis use disorder
Background Variation in liability to cannabis use disorder has a strong genetic component
(estimated twin and family heritability about 50–70%) and is associated with negative …
(estimated twin and family heritability about 50–70%) and is associated with negative …
GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability
Cannabis use is a heritable trait that has been associated with adverse mental health
outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to …
outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to …
Genome-wide association study identifies a novel locus for cannabis dependence
Despite moderate heritability, only one study has identified genome-wide significant loci for
cannabis-related phenotypes. We conducted meta-analyses of genome-wide association …
cannabis-related phenotypes. We conducted meta-analyses of genome-wide association …
Cannabis dependence in the San Francisco Family Study: age of onset of use, DSM-IV symptoms, withdrawal, and heritability
Cannabis is the most widely used illicit drug in the United States, yet the role of genetics in
individual symptoms associated with cannabis use disorders has not been evaluated. The …
individual symptoms associated with cannabis use disorders has not been evaluated. The …
Genetic predisposition vs individual-specific processes in the association between psychotic-like experiences and cannabis use
Importance Previous research indicates that cannabis use is associated with psychotic-like
experiences (PLEs). However, it is unclear whether this association results from …
experiences (PLEs). However, it is unclear whether this association results from …
Cannabis controversies: how genetics can inform the study of comorbidity
A Agrawal, MT Lynskey - Addiction, 2014 - Wiley Online Library
Aims To review three key and controversial comorbidities of cannabis use—other illicit drug
use, psychosis and depression, as well as suicide, from a genetically informed perspective …
use, psychosis and depression, as well as suicide, from a genetically informed perspective …
[HTML][HTML] Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications
As recreational use of cannabis is being decriminalized in many places and medical use
widely sanctioned, there are growing concerns about increases in cannabis use disorder …
widely sanctioned, there are growing concerns about increases in cannabis use disorder …
[HTML][HTML] Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis …
Cannabis is the most widely produced and consumed illicit psychoactive substance
worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence …
worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence …