New insights into RA genetics from GWAS meta-analysis

S Onuora - Nature Reviews Rheumatology, 2021 - nature.com
Nearly 110 susceptibility loci for rheumatoid arthritis (RA) have been identified in population-
based genetic association studies; however, these variants account for only a small …

Large-scale meta-analysis across East Asian and European populations updated genetic architecture and variant-driven biology of rheumatoid arthritis, identifying 11 …

E Ha, SC Bae, K Kim - Annals of the rheumatic diseases, 2021 - ard.bmj.com
Objectives Nearly 110 susceptibility loci for rheumatoid arthritis (RA) with modest effect sizes
have been identified by population-based genetic association studies, suggesting a large …

Update on the genetic risk factors for rheumatoid arthritis

G Orozco, A Barton - Expert Review of Clinical Immunology, 2010 - Taylor & Francis
Rheumatoid arthritis (RA) is a complex disease, meaning that multiple genetic variants,
environmental factors and random events interact to trigger pathological pathways. Although …

RAvariome: a genetic risk variants database for rheumatoid arthritis based on assessment of reproducibility between or within human populations

Y Nagai, T Imanishi - Database, 2013 - academic.oup.com
Rheumatoid arthritis (RA) is a common autoimmune inflammatory disease of the joints and
is caused by both genetic and environmental factors. In the past six years, genome-wide …

A Genome‐Wide Association Study Reveals ARL15, a Novel Non‐HLA Susceptibility Gene for Rheumatoid Arthritis in North Indians

S Negi, G Juyal, S Senapati, P Prasad… - Arthritis & …, 2013 - Wiley Online Library
Objective Genome‐wide association studies (GWAS) and their subsequent meta‐analyses
have changed the landscape of genetics in rheumatoid arthritis (RA) by uncovering several …

Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans

L Jiang, J Yin, L Ye, J Yang, G Hemani… - Arthritis & …, 2014 - Wiley Online Library
Objective To investigate differences in genetic risk factors for rheumatoid arthritis (RA) in
Han Chinese as compared with Europeans. Methods A genome‐wide association study was …

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

EA Stahl, S Raychaudhuri, EF Remmers, G Xie… - Nature …, 2010 - nature.com
To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …

Genetics of RA susceptibility, what comes next?

J Ding, S Eyre, J Worthington - RMD open, 2015 - rmdopen.bmj.com
Genome-wide association studies (GWASs) have been used to great effect to identify
genetic susceptibility loci for complex disease. A series of GWAS and meta-analyses have …

Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers

D Plant, E Flynn, H Mbarek, P Dieudé… - Annals of the …, 2010 - ard.bmj.com
Background Genetic factors have a substantial role in determining development of
rheumatoid arthritis (RA), and are likely to account for 50–60% of disease susceptibility …

Integrative analyses for functional mechanisms underlying associations for rheumatoid arthritis

FY Deng, SF Lei, H Zhu, YH Zhang… - The Journal of …, 2013 - jrheum.org
Objective. Extensive association analyses including genome-wide association studies
(GWAS) and powerful metaanalysis studies have identified a long list of loci associated with …