Evaluation of endothelial dysfunction and inflammatory vasculopathy after SARS-CoV-2 infection—a cross-sectional study

P Jud, P Gressenberger, V Muster, A Avian… - Frontiers in …, 2021 - frontiersin.org
Background: Rising data suggest that COVID-19 affects vascular endothelium while the
underlying mechanisms promoting COVID-19-associated endothelial dysfunction and …

Endothelial dysfunction in SARS-CoV-2 infection

F Nappi, SS Avtaar Singh - Biomedicines, 2022 - mdpi.com
One of the hallmarks of the SARS-CoV-2 infection has been the inflammatory process that
played a role in its pathogenesis, resulting in mortality within susceptible individuals. This …

Vascular manifestations of COVID-19–thromboembolism and microvascular dysfunction

KA Roberts, L Colley, TA Agbaedeng… - Frontiers in …, 2020 - frontiersin.org
The coronavirus pandemic has reportedly infected over 31.5 million individuals and caused
over 970,000 deaths worldwide (as of 22nd Sept 2020). This novel coronavirus, officially …

SARS-CoV-2 causes severe epithelial inflammation and barrier dysfunction

S Deinhardt-Emmer, S Böttcher, C Häring… - Journal of …, 2021 - Am Soc Microbiol
Infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be
asymptomatic, but they can also be accompanied by a variety of symptoms that result in mild …

The endothelium as a target for infections

G Valbuena, DH Walker - Annu. Rev. Pathol. Mech. Dis., 2006 - annualreviews.org
The endothelial cells lining vascular and lymphatic vessels are targets of several infectious
agents, including viruses and bacteria, that lead to dramatic changes in their functions …

Endothelial injury in COVID-19 and acute infections: putting the pieces of the puzzle together

JH Levy, T Iba, EE Gardiner - Arteriosclerosis, Thrombosis, and …, 2021 - Am Heart Assoc
(SARS-CoV2), also known as coronavirus disease 2019 (COVID-19), COVID-19–associated
coagulopathy is a major challenge with a high incidence of thromboembolic complications. 1 …

COVID-19 and microvascular disease: pathophysiology of SARS-CoV-2 infection with focus on the renin-angiotensin system

DA Kasal, A De Lorenzo, E Tibirica - Heart, Lung and Circulation, 2020 - Elsevier
The recently described severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
infected millions of people, with thousands of fatalities. It has prompted global efforts in …

Endothelial cell infection and endotheliitis in COVID-19

Z Varga, AJ Flammer, P Steiger, M Haberecker… - The Lancet, 2020 - thelancet.com
Cardiovascular complications are rapidly emerging as a key threat in coronavirus disease
2019 (COVID-19) in addition to respiratory disease. The mechanisms underlying the …

Mechanisms of SARS-CoV-2-induced lung vascular disease: potential role of complement

KR Stenmark, MG Frid… - Pulmonary …, 2021 - journals.sagepub.com
The outbreak of COVID-19 disease, caused by SARS-CoV-2 beta-coronovirus, urges a
focused search for the underlying mechanisms and treatment options. The lung is the major …

Senescent endothelial cells are predisposed to SARS-CoV-2 infection and subsequent endothelial dysfunction

R Urata, K Ikeda, E Yamazaki, D Ueno, A Katayama… - Scientific Reports, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19), caused by the novel severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), remains to spread worldwide. COVID-19 …