Cholesterol has been implicated in the pathogenesis of Alzheimer's disease, both through
intracellular effects, and through an extracellular effect due to its physical interaction with …

Recent results implicating cholesterol metabolism in the pathophysiology of Alzheimer's
disease (AD) bring cholesterol to the forefront of AD research. Research from genetics …

The accumulation and aggregation of the amyloid-β peptide (Aβ) in the brain are important
contributing factors to Alzheimer's disease (AD). Consequently, blocking the generation of …

A large amount of evidence suggests a pathogenic link between cholesterol homeostasis
dysregulation and Alzheimer's disease (AD). In cell culture systems, the production of …

High serum/plasma cholesterol levels have been suggested as a risk factor for Alzheimer's
disease (AD). Some reports, mostly retrospective epidemiological studies, have observed a …

Clinical, epidemiological, and laboratory studies suggest that cholesterol may play a role in
the pathogenesis of Alzheimer's disease (AD). Transgenic mice exhibiting an Alzheimer's β …

Molecular and more specifically subcellular analyses of the neurodegenerative mechanisms
involved in Alzheimer's disease (AD) had been considered most of the time an interplay of …

Fundamental questions on the pathogenesis of Alzheimer's disease (AD) are how nontoxic,
soluble amyloid β‐protein (Aβ) is converted to its toxic, aggregated form and how functional …

Alzheimer's disease (AD), the most common form of dementia, is characterized by the
progressive loss of neurons and synapses, and by extracellular deposits of amyloid‐β (Aβ) …

Evidence is accumulating to suggest that cholesterol is a potent risk factor for the
development of Alzheimer's disease. An increase in cholesterol level in neuronal …