Neuroprotection of edaravone on the hippocampus of kainate-induced epilepsy rats through Nrf2/HO-1 pathway

Z Liu, C Yang, X Meng, Z Li, C Lv, P Cao - Neurochemistry international, 2018 - Elsevier
Epilepsy is a severe and chronic neurological disease. Edaravone is an effective free radical
scavenger and has been reported to prevent neuronal loss induced by Kainate (KA) …

Rosmarinic acid exerts a neuroprotective effect in the kainate rat model of temporal lobe epilepsy: Underlying mechanisms

S Khamse, SS Sadr, M Roghani… - Pharmaceutical …, 2015 - Taylor & Francis
Context: Temporal lobe epilepsy (TLE) is an intractable neurological disorder. Rosmarinic
acid (RA) is a natural polyphenol with antioxidant, anti-apoptotic, and anti-inflammatory …

Alpha-pinene exerts antiseizure effects by preventing oxidative stress and apoptosis in the hippocampus in a rat model of temporal lobe epilepsy induced by kainate

P Hashemi, S Ahmadi - Molecular Neurobiology, 2023 - Springer
Oxidative stress and apoptosis following seizures play pivotal roles in the consequences of
repeated seizures. Beneficial effects of alpha-pinene (APN) have been reported in some …

Coenzyme q10 ameliorates neurodegeneration, mossy fiber sprouting, and oxidative stress in intrahippocampal kainate model of temporal lobe epilepsy in rat

T Baluchnejadmojarad, M Roghani - Journal of Molecular Neuroscience, 2013 - Springer
Temporal lobe epilepsy (TLE) is the most common form of epilepsy in adults and the most
resistant type to treatment. Novel treatment approaches are strongly required to prevent or …

Paeonol exerts neuroprotective and anticonvulsant effects in intrahippocampal kainate model of temporal lobe epilepsy

S Ramazi, J Fahanik-Babaei… - Journal of Chemical …, 2022 - Elsevier
Temporal lobe epilepsy (TLE) is presented the most common form of focal epilepsy with
involvement of oxidative stress and neuroinflammation as important factors in its …

Huperzine A ameliorates cognitive dysfunction and neuroinflammation in kainic acid‐induced epileptic rats by antioxidant activity and NLRP 3/caspase‐1 pathway …

P Mohseni‐Moghaddam, SS Sadr… - Clinical and …, 2019 - Wiley Online Library
Temporal lobe epilepsy (TLE) is one of the most prevalent types of epilepsy in human.
Huperzine A (Hup‐A) has been reported to possess antioxidative and anti‐inflammatory …

Genistein protects epilepsy-induced brain injury through regulating the JAK2/STAT3 and Keap1/Nrf2 signaling pathways in the developing rats

Q Hu, H Yan, F Peng, W Feng, F Chen, X Huang… - European Journal of …, 2021 - Elsevier
Background Epilepsy is a common chronic neurological disease. Recurrent seizures can
cause irreversible brain damage. This study aimed to explore the regulation of Genistein on …

Neuroprotective and anticonvulsant effects of sinomenine in kainate rat model of temporal lobe epilepsy: Involvement of oxidative stress, inflammation and pyroptosis

S Ramazi, J Fahanik-Babaei… - Journal of chemical …, 2020 - Elsevier
Oxidative stress, inflammation and pyroptosis are three of the most important mechanisms in
the pathophysiology of temporal lobe epilepsy (TLE). Most people with TLE are refractory to …

[HTML][HTML] Ginsenoside Rb1 protects the brain from damage induced by epileptic seizure via Nrf2/ARE signaling

Y Shi, W Miao, J Teng, L Zhang - Cellular Physiology and Biochemistry, 2018 - karger.com
Background/Aims: Ginsenoside Rb1 (Rb1) has been reported to have varieties of
neuroprotective effects. This study aimed to evaluate the effects of Rb1 on pentylenetetrazol …

Everolimus inhibits PI3K/Akt/mTOR and NF-kB/IL-6 signaling and protects seizure-induced brain injury in rats

X Huang, Q Hu, H Shi, Y Zheng, R Hu, Q Guo - Journal of Chemical …, 2021 - Elsevier
Background Epilepsy is a common chronic neurological disease caused by the over-
synchronization of neurons leading to brain dysfunction. Recurrent seizures can lead to …