Enhancing nutraceutical performance using excipient foods: Designing food structures and compositions to increase bioavailability

DJ McClements, L Zou, R Zhang… - … Reviews in Food …, 2015 - Wiley Online Library
The oral bioavailability of many bioactives (pharmaceuticals, dietary supplements, nutrients,
and nutraceuticals) is limited because of physicochemical and physiological events that …

Excipient foods: designing food matrices that improve the oral bioavailability of pharmaceuticals and nutraceuticals

DJ McClements, H Xiao - Food & Function, 2014 - pubs.rsc.org
The oral bioavailability of many lipophilic bioactive agents (pharmaceuticals and
nutraceuticals) is limited due to various physicochemical and physiological processes: poor …

Utilizing food effects to overcome challenges in delivery of lipophilic bioactives: structural design of medical and functional foods

DJ McClements - Expert opinion on drug delivery, 2013 - Taylor & Francis
Introduction: The oral bioavailability of many lipophilic bioactives, such as pharmaceuticals
and nutraceuticals, is relatively low due to their poor solubility, permeability and/or chemical …

Boosting the bioavailability of hydrophobic nutrients, vitamins, and nutraceuticals in natural products using excipient emulsions

DJ McClements, L Saliva-Trujillo, R Zhang… - Food Research …, 2016 - Elsevier
Many highly hydrophobic bioactives, such as non-polar nutrients, nutraceuticals, and
vitamins, have a relatively low or variable oral bioavailability. The poor bioavailability profile …

Enhancing nutraceutical bioavailability by controlling the composition and structure of gastrointestinal contents: Emulsion-based delivery and excipient systems

R Zhang, DJ McClements - Food structure, 2016 - Elsevier
The oral bioavailability of hydrophobic bioactives can be improved using food matrices that
breakdown within the gastrointestinal tract to form colloidal structures capable of altering …

Delivery of bioactives in food for optimal efficacy: What inspirations and insights can be gained from pharmaceutics?

E Nowak, YD Livney, Z Niu, H Singh - Trends in Food Science & …, 2019 - Elsevier
Background Increasing health awareness, together with mounting literature on the health
benefits of nutraceuticals, has propelled a plethora of studies for introducing delivery …

A review on the relationship between food structure, processing, and bioavailability

I Sensoy - Critical reviews in food science and nutrition, 2014 - Taylor & Francis
This review highlights the effects of processing and food matrix on bioaccessibility and
bioavailability of functional components. Human digestive system is reviewed as an element …

Oral delivery strategies for nutraceuticals: Delivery vehicles and absorption enhancers

JP Gleeson, SM Ryan, DJ Brayden - Trends in Food Science & Technology, 2016 - Elsevier
Background Lifestyle issues contribute to the development of obesity, type 2 diabetes, and
cardiovascular disease. Together with appropriate diet and exercise, nutraceuticals may …

A review of recent progress in improving the bioavailability of nutraceutical‐loaded emulsions after oral intake

X Chen, Y Chen, Y Liu, L Zou… - … Reviews in Food …, 2022 - Wiley Online Library
Increasing awareness of the health benefits of specific constituents in fruits, vegetables,
cereals, and other whole foods has sparked a broader interest in the potential health …

The nutraceutical bioavailability classification scheme: classifying nutraceuticals according to factors limiting their oral bioavailability

DJ McClements, F Li, H Xiao - Annual review of food science …, 2015 - annualreviews.org
The oral bioavailability of a health-promoting dietary component (nutraceutical) may be
limited by various physicochemical and physiological phenomena: liberation from food …