Erythropoietin and the heart: physiological effects and the therapeutic perspective

F Sanchis-Gomar, JL Garcia-Gimenez… - International journal of …, 2014 - Elsevier
Erythropoietin (Epo) has been thought to act exclusively on erythroid progenitor cells. The
identification of Epo receptor (EpoR) in non-haematopoietic cells and tissues including …

Erythropoietin in cardiac disease: effective or harmful?

V Mastromarino, MB Musumeci, E Conti… - Journal of …, 2013 - journals.lww.com
Discovered as the primary regulator of erythropoiesis, erythropoietin (EPO) is involved in a
broad variety of processes that play a major role in cardiovascular diseases. In particular …

An update on the cardiac effects of erythropoietin cardioprotection by erythropoietin and the lessons learnt from studies in neuroprotection

MA Bogoyevitch - Cardiovascular research, 2004 - academic.oup.com
Erythropoietin (Epo) was once thought to act exclusively in the formation of red blood cells.
As recently reviewed by Smith et al.[Cardiovasc. Res. 59 (2003) 538–548], Epo can also act …

Molecular basis of cardioprotection by erythropoietin

D Burger, A Xenocostas… - Current molecular …, 2009 - ingentaconnect.com
Erythropoietin (EPO), a glycoprotein essential for red blood cell production acts on several
non-erythropoietic tissues. The EPO receptor (EPOR) is expressed in a variety of cell types …

Protective effects of erythropoietin in cardiac ischemia: from bench to bedside

E Lipšic, RG Schoemaker, P van der Meer… - Journal of the American …, 2006 - jacc.org
Erythropoietin (EPO) is a hypoxia-induced hormone produced in the kidneys that stimulates
hematopoiesis in the bone marrow. However, recent studies have also shown important …

Current perspectives on protective roles of erythropoietin in cardiovascular system: erythropoietin receptor as a novel therapeutic target

Y Kagaya, Y Asaumi, W Wang, M Takeda… - The Tohoku Journal of …, 2012 - jstage.jst.go.jp
Erythropoietin (EPO) is a principal regulator that promotes proliferation and terminal
differentiation of erythroid progenitor cells. EPO receptors are expressed not only in …

Structure, production and function of erythropoietin: implications for therapeutical use in cardiovascular disease

D Mocini, T Leone, M Tubaro… - Current medicinal …, 2007 - ingentaconnect.com
Erythropoietin (EPO) is a 30,400 daltons glycoprotein, consisting of 165 amino acids
produced mainly in the kidney and in the liver and regulating erythrocyitosis. It primarily acts …

Do non-hemopoietic effects of erythropoietin play a beneficial role in heart failure?

R Latini, M Brines, F Fiordaliso - Heart failure reviews, 2008 - Springer
Erythropoietin (EPO) is not solely a hormone charged with regulating the proliferation and
differentiation of erythroid cells. Indeed, EPO is synthesized locally by many cells, especially …

What is the role of erythropoietin in acute myocardial infarct? Bridging the gap between experimental models and clinical trials

F Roubille, F Prunier, S Barrère-Lemaire… - … drugs and therapy, 2013 - Springer
Erythropoietin (EPO) is the main hormone that regulates erythropoiesis. Beyond its well-
known hematopoietic action, EPO has diverse cellular effects in non-hematopoietic tissues …

Beyond erythropoiesis: the anti-inflammatory effects of erythropoietin

Q Feng - Cardiovascular research, 2006 - academic.oup.com
Erythropoietin (EPO) is a 30.4-kDa glycoprotein essential for red blood cell production. In
adults, EPO is produced primarily in the kidney via an oxygen-sensing mechanism and …