More than any other cytokine family, the interleukin (IL)-1 family is closely linked to the
innate immune response. This linkage became evident upon the discovery that the …

This issue of Seminars in Immunology on The Interleukin-1 (IL-1) Family of Ligands and
Receptors updates the rapidly expanding importance of this family. There are individual …

More than any other family, the IL-1 Family of 11 cytokines and 10 receptors provides the
host with an endogenous innate immune system, whereas the family of Toll-like Receptors …

The activity of each member of the IL-1 family of ligands is mediated by its own receptor.
Each ligand binds specifically to the extracellular “ligand binding chain” containing three Ig …

More than any other cytokine family, the IL-1 family of ligands and receptors is primarily
associated with acute and chronic inflammation. The cytosolic segment of each IL-1 receptor …

Summary The interleukin‐1 (IL‐1) family of cytokines and receptors is unique in immunology
because the IL‐1 family and Toll‐like receptor (TLR) families share similar functions. More …

The signal transduction pathways activated by the proinflammatory cytokine interleukin-1 (IL-
1) have been the focus of much attention because of the important role that IL-1 plays in …

The signal transduction pathways activated by the proinflammatory cytokine interleukin-1 (IL-
1) have been the focus of much attention because of the important role that IL-1 plays in …

The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host
defense: Immunology Today Skip to Main Content Skip to Main Menu Advertisement Trends in …

A novel member of the interleukin 1 receptor (IL-1R) superfamily, SIGIRR (single Ig IL-1R-
related molecule) was identified in mouse and human. Although it shows the typical …