R Du, C Huang, K Liu, X Li, Z Dong - Molecular cancer, 2021 - Springer
Aurora kinase A (AURKA) belongs to the family of serine/threonine kinases, whose activation is necessary for cell division processes via regulation of mitosis. AURKA shows …
H Fatma, HR Siddique - … in Protein Chemistry and Structural Biology, 2023 - europepmc.org
Aurora-A kinase (AURKA) belongs to the serine/threonine kinase family specific to cell division. In normal cells, activation of the AURKA protein is essential for regulating …
Aurora Kinase A (AURKA) is a positive regulator of mitosis with a strict cell cycle-dependent expression pattern. Recently, novel oncogenic roles of AURKA have been uncovered that …
G Bertolin, M Tramier - Cellular and Molecular Life Sciences, 2020 - Springer
AURKA is a serine/threonine kinase overexpressed in several cancers. Originally identified as a protein with multifaceted roles during mitosis, improvements in quantitative microscopy …
C Yang, PS Plum, I Gockel, R Thieme - Frontiers in Oncology, 2023 - frontiersin.org
Background Aurora kinase A (AURKA) plays a pivotal role in regulating cell mitosis and tumor progression. However, its prognostic significance across diverse cancer types …
K Sankhe, A Prabhu, T Khan - Chemical biology & drug design, 2021 - Wiley Online Library
Aurora kinases (AURKs) are serine/threonine protein kinases that play a critical role during cell proliferation. Three isoforms of AURKs reported in mammals include AURKA, AURKB …
PK Mou, EJ Yang, C Shi, G Ren, S Tao… - Experimental & Molecular …, 2021 - nature.com
Recent advances in high-throughput sequencing technologies and data science have facilitated the development of precision medicine to treat cancer patients. Synthetic lethality …
A Katsha, A Belkhiri, L Goff, W El-Rifai - Molecular cancer, 2015 - Springer
Gastrointestinal (GI) cancers are a major cause of cancer-related deaths. During the last two decades, several studies have shown amplification and overexpression of Aurora kinase A …
The Aurora family of serine/threonine kinases in mammals are key regulators of mitotic progression and are commonly upregulated in human tumors. Since AURKA's increased …