The significant others of aurora kinase a in cancer: combination is the key

K Nikhil, K Shah - Biomarker Research, 2024 - Springer
AURKA is predominantly famous as an essential mitotic kinase. Recent findings have also
established its critical role in a plethora of other biological processes including ciliogenesis …

Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy

R Du, C Huang, K Liu, X Li, Z Dong - Molecular cancer, 2021 - Springer
Aurora kinase A (AURKA) belongs to the family of serine/threonine kinases, whose
activation is necessary for cell division processes via regulation of mitosis. AURKA shows …

AURORA KINASE A and related downstream molecules: A potential network for cancer therapy.

H Fatma, HR Siddique - … in Protein Chemistry and Structural Biology, 2023 - europepmc.org
Aurora-A kinase (AURKA) belongs to the serine/threonine kinase family specific to cell
division. In normal cells, activation of the AURKA protein is essential for regulating …

Regulating the regulator: a survey of mechanisms from transcription to translation controlling expression of mammalian cell cycle kinase Aurora A

R Cacioppo, C Lindon - Open Biology, 2022 - royalsocietypublishing.org
Aurora Kinase A (AURKA) is a positive regulator of mitosis with a strict cell cycle-dependent
expression pattern. Recently, novel oncogenic roles of AURKA have been uncovered that …

Insights into the non-mitotic functions of Aurora kinase A: more than just cell division

G Bertolin, M Tramier - Cellular and Molecular Life Sciences, 2020 - Springer
AURKA is a serine/threonine kinase overexpressed in several cancers. Originally identified
as a protein with multifaceted roles during mitosis, improvements in quantitative microscopy …

Pan-cancer analysis and in vitro validation of the oncogenic and prognostic roles of AURKA in human cancers

C Yang, PS Plum, I Gockel, R Thieme - Frontiers in Oncology, 2023 - frontiersin.org
Background Aurora kinase A (AURKA) plays a pivotal role in regulating cell mitosis and
tumor progression. However, its prognostic significance across diverse cancer types …

Design strategies, SAR, and mechanistic insight of Aurora kinase inhibitors in cancer

K Sankhe, A Prabhu, T Khan - Chemical biology & drug design, 2021 - Wiley Online Library
Aurora kinases (AURKs) are serine/threonine protein kinases that play a critical role during
cell proliferation. Three isoforms of AURKs reported in mammals include AURKA, AURKB …

Aurora kinase A, a synthetic lethal target for precision cancer medicine

PK Mou, EJ Yang, C Shi, G Ren, S Tao… - Experimental & Molecular …, 2021 - nature.com
Recent advances in high-throughput sequencing technologies and data science have
facilitated the development of precision medicine to treat cancer patients. Synthetic lethality …

Aurora kinase A in gastrointestinal cancers: time to target

A Katsha, A Belkhiri, L Goff, W El-Rifai - Molecular cancer, 2015 - Springer
Gastrointestinal (GI) cancers are a major cause of cancer-related deaths. During the last two
decades, several studies have shown amplification and overexpression of Aurora kinase A …

Targeting aurora kinase a (AURKA) in cancer: molecular docking and dynamic simulations of potential AURKA inhibitors

A Almilaibary - Medical Oncology, 2022 - Springer
The Aurora family of serine/threonine kinases in mammals are key regulators of mitotic
progression and are commonly upregulated in human tumors. Since AURKA's increased …