SARS-CoV-2 takes its Toll

A Sariol, S Perlman - Nature immunology, 2021 - nature.com
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Ubiquitination of SARS-CoV-2 NSP6 and ORF7a facilitates NF-κB activation

H Nishitsuji, S Iwahori, M Ohmori, K Shimotohno… - MBio, 2022 - Am Soc Microbiol
Patients with severe coronavirus disease 2019 tend to have high levels of proinflammatory
cytokines, which eventually lead to cytokine storm and the development of acute respiratory …

Cytokines and chemokines in SARS-CoV-2 infections—therapeutic strategies targeting cytokine storm

A Pum, M Ennemoser, T Adage, AJ Kungl - Biomolecules, 2021 - mdpi.com
The recently identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
virus, the cause of coronavirus disease (COVID-19) and the associated ongoing pandemic …

SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation

S Li, Y Zhang, Z Guan, H Li, M Ye, X Chen… - Signal transduction and …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to
respiratory illness and multi-organ failure in critically ill patients. Although the virus-induced …

Increased serum levels of soluble TNF-α receptor is associated with ICU mortality in COVID-19 patients

E Mortaz, P Tabarsi, H Jamaati… - Frontiers in …, 2021 - frontiersin.org
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes
coronavirus disease 2019 (COVID-19) has infected over 112M patients and resulted in …

Role of pirfenidone in TGF-β pathways and other inflammatory pathways in acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection: a theoretical …

SH Hamidi, S Kadamboor Veethil, SH Hamidi - Pharmacological Reports, 2021 - Springer
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
pulmonary injury or multiple-organ injury by various pathological pathways. Transforming …

Interleukin-6 is a biomarker for the development of fatal severe acute respiratory syndrome coronavirus 2 pneumonia

A Santa Cruz, A Mendes-Frias, AI Oliveira… - Frontiers in …, 2021 - frontiersin.org
Hyper-inflammatory responses induced by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) are a major cause of disease severity and death. Predictive prognosis …

Treatment of severe COVID-19 with tocilizumab mitigates cytokine storm and averts mechanical ventilation during acute respiratory distress: a case report and …

F Farooqi, N Dhawan, R Morgan, J Dinh… - Tropical medicine and …, 2020 - mdpi.com
COVID-19, caused by the novel severe acute respiratory coronavirus 2 (SARS-CoV-2),
emerged in Wuhan, China, in 2019 and has resulted in the current pandemic. The disease …

Updated insights into the T cell-mediated immune response against SARS-CoV-2: a step towards efficient and reliable vaccines

M Dhawan, AA Rabaan, MMA Fawarah, SA Almuthree… - Vaccines, 2023 - mdpi.com
The emergence of novel variants of SARS-CoV-2 and their abilities to evade the immune
response elicited through presently available vaccination makes it essential to recognize the …

Innate immunity, cytokine storm, and inflammatory cell death in COVID-19

R Karki, TD Kanneganti - Journal of Translational Medicine, 2022 - Springer
The innate immune system serves as the first line of defense against invading pathogens;
however, dysregulated innate immune responses can induce aberrant inflammation that is …