Neurodegeneration and neuroinflammation in diabetic retinopathy: potential approaches to delay neuronal loss

L Malaguarnera, K Zorena - Current neuropharmacology, 2016 - ingentaconnect.com
In spite of the extensive research the complex pathogenesis of diabetic retinopathy (DR) has
not been fully elucidated. For many years it has been thought that diabetic retinopathy …

Diabetic retinopathy: neuron protection as a therapeutic target

X Zhang, N Wang, GR Barile, S Bao, M Gillies - The international journal of …, 2013 - Elsevier
Diabetic retinopathy (DR) has mainly been regarded as a microvascular disease that is
caused by hyperglycaemia and characterized by retinal vascular leakage, macular oedema …

Neurodegeneration in diabetic retinopathy: does it really matter?

R Simó, AW Stitt, TW Gardner - Diabetologia, 2018 - Springer
The concept of diabetic retinopathy as a microvascular disease has evolved, in that it is now
considered a more complex diabetic complication in which neurodegeneration plays a …

Retinal neurodegeneration in the course of diabetes-pathogenesis and clinical perspective

A Araszkiewicz… - Current …, 2016 - ingentaconnect.com
Diabetic retinopathy is generally considered as a microvascular disease which develops as
a result of chronic hyperglycaemia. However, the neuronal apoptosis and reactive gliosis …

[HTML][HTML] Diabetic retinopathy: role of neurodegeneration and therapeutic perspectives

R Simo, O Simo-Servat, P Bogdanov… - Asia-Pacific Journal of …, 2022 - Elsevier
Retinal neurodegeneration plays a significant role in the pathogenesis of diabetic
retinopathy, the leading cause of preventable blindness. The hallmarks of diabetes-induced …

Retinal neurodegeneration: early pathology in diabetes

E Lieth, TW Gardner, AJ Barber… - Clinical & Experimental …, 2000 - Wiley Online Library
Normal vision depends on the normal function of retinal neurons, so vision loss in diabetes
must ultimately be explained in terms of altered neuronal function. However, to date …

Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives

R Simo, C Hernández - Trends in Endocrinology & Metabolism, 2014 - cell.com
Diabetic retinopathy (DR), one of the leading causes of preventable blindness, has been
considered a microcirculatory disease of the retina. However, there is emerging evidence to …

[HTML][HTML] Neurodegeneration: an early event of diabetic retinopathy

M Villarroel, A Ciudin, C Hernández… - World journal of …, 2010 - ncbi.nlm.nih.gov
Diabetic retinopathy (DR) has been classically considered to be a microcirculatory disease
of the retina caused by the deleterious metabolic effects of hyperglycemia per se and the …

[HTML][HTML] Neurodegeneration in diabetic retinopathy: potential for novel therapies

AJ Barber, B Baccouche - Vision research, 2017 - Elsevier
The complex pathology of diabetic retinopathy (DR) affects both vascular and neural tissue.
The characteristics of neurodegeneration are well-described in animal models but have …

Neurovascular cell death and therapeutic strategies for diabetic retinopathy

T Oshitari - International Journal of Molecular Sciences, 2023 - mdpi.com
Diabetic retinopathy (DR) is a major complication of diabetes and a leading cause of
blindness worldwide. DR was recently defined as a neurovascular disease associated with …