SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals
SARS-CoV-2 has a zoonotic origin and was transmitted to humans via an undetermined
intermediate host, leading to infections in humans and other mammals. To enter host cells …
intermediate host, leading to infections in humans and other mammals. To enter host cells …
[HTML][HTML] Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B. 1.1. 7 variant
C Graham, J Seow, I Huettner, H Khan, N Kouphou… - Immunity, 2021 - cell.com
Interaction of the SARS-CoV-2 Spike receptor binding domain (RBD) with the receptor ACE2
on host cells is essential for viral entry. RBD is the dominant target for neutralizing …
on host cells is essential for viral entry. RBD is the dominant target for neutralizing …
[HTML][HTML] Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: An in silico analysis
Many human viral diseases are a consequence of a zoonotic event. Some of the diseases
caused by these zoonotic events have affected millions of people around the world, some of …
caused by these zoonotic events have affected millions of people around the world, some of …
Enhanced binding of the N501Y‐mutated SARS‐CoV‐2 spike protein to the human ACE2 receptor: insights from molecular dynamics simulations
Recently, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants (B. 1.1.
7 and B. 1351) have emerged harbouring mutations that make them highly contagious. The …
7 and B. 1351) have emerged harbouring mutations that make them highly contagious. The …
Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2
Dear Editor, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a
severe threat to global health. 1 The spike (S) protein on the surface of SARS-CoV-2 exploits …
severe threat to global health. 1 The spike (S) protein on the surface of SARS-CoV-2 exploits …
Scanning the RBD-ACE2 molecular interactions in Omicron variant
The emergence of new SARS-CoV-2 variants poses a threat to the human population where
it is difficult to assess the severity of a particular variant of the virus. Spike protein and …
it is difficult to assess the severity of a particular variant of the virus. Spike protein and …
Bioinformatics analysis of the differences in the binding profile of the wild-type and mutants of the SARS-CoV-2 spike protein variants with the ACE2 receptor
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
coronavirus disease 2019 (COVID-19). Reports of new variants that potentially increase …
coronavirus disease 2019 (COVID-19). Reports of new variants that potentially increase …
The molecular basis for SARS-CoV-2 binding to dog ACE2
SARS-CoV-2 can infect many domestic animals, including dogs. Herein, we show that dog
angiotensin-converting enzyme 2 (dACE2) can bind to the SARS-CoV-2 spike (S) protein …
angiotensin-converting enzyme 2 (dACE2) can bind to the SARS-CoV-2 spike (S) protein …
Molecular docking simulation reveals ACE2 polymorphisms that may increase the affinity of ACE2 with the SARS-CoV-2 Spike protein
There is increasing evidence that ACE2 gene polymorphism can modulate the interaction
between ACE2 and the SARS-CoV-2 spike protein affecting the viral entry into the host cell …
between ACE2 and the SARS-CoV-2 spike protein affecting the viral entry into the host cell …
In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding
N Bate, CG Savva, PCE Moody, EA Brown… - PLoS …, 2022 - journals.plos.org
Emerging SARS-CoV-2 variants are creating major challenges in the ongoing COVID-19
pandemic. Being able to predict mutations that could arise in SARS-CoV-2 leading to …
pandemic. Being able to predict mutations that could arise in SARS-CoV-2 leading to …