Abstract The programmed death-1 (PD-1) receptor serves as an immunologic checkpoint,
limiting bystander tissue damage and preventing the development of autoimmunity during …

Abstract The Programmed Death-1 (PD-1) receptor delivers inhibitory checkpoint signals to
activated T cells upon binding to its ligands PD-L1 and PD-L2 expressed on antigen …

Introduction Programmed cell death-1 (PD-1) is an immune checkpoint receptor that inhibits
T cell activation upon interaction with its ligands PD-L1 or PD-L2. Increased PD-L1 …

ABSTRACT Programmed death-1 (PD-1) is a cell surface receptor that functions as a T cell
checkpoint and plays a central role in regulating T cell exhaustion. Binding of PD-1 to its …

Background Programmed death 1 (PD-1) protein, a T-cell coinhibitory receptor, and one of
its ligands, PD-L1, play a pivotal role in the ability of tumor cells to evade the host's immune …

Targeted immunotherapy has become the most promising approach for tumor patients.
Programmed death-1 (PD-1), an inhibitory receptor expressed on activated T cells, can …

Background This study evaluated the safety, tolerability, pharmacokinetics, immunogenicity
and antitumor activity of single and multiple doses of nivolumab in Japanese patients with …

Blocking the programmed death-1 (PD-1) pathway has clinical benefit in metastatic cancer
and has led to the approval of the mAbs pembrolizumab and nivolumab to treat melanoma …

The programmed cell death 1 (PD-1) receptor on the surface of immune cells is an immune
checkpoint molecule that mediates the immune escape of tumor cells. Consequently …

Abstract Programmed death-1 (PD-1) is a co-receptor that is expressed predominantly by T
cells. The binding of PD-1 to its ligands, PD-L1 or PD-L2, is vital for the physiologic …