Effects of chronic cannabidiol in a mouse model of naturally occurring neuroinflammation, neurodegeneration, and spontaneous seizures

JT Dearborn, HR Nelvagal, NR Rensing… - Scientific reports, 2022 - nature.com
Cannabidiol (CBD) has gained attention as a therapeutic agent and is purported to have
immunomodulatory, neuroprotective, and anti-seizure effects. Here, we determined the …

[HTML][HTML] Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures

NA Jones, SE Glyn, S Akiyama, TDM Hill, AJ Hill… - Seizure, 2012 - Elsevier
Cannabis sativa has been associated with contradictory effects upon seizure states despite
its medicinal use by numerous people with epilepsy. We have recently shown that the …

Molecular targets of cannabidiol in experimental models of neurological disease

S Silvestro, G Schepici, P Bramanti, E Mazzon - Molecules, 2020 - mdpi.com
Cannabidiol (CBD) is a non-psychoactive phytocannabinoid known for its beneficial effects
including antioxidant and anti-inflammatory properties. Moreover, CBD is a compound with …

Effects of orally administered cannabidiol on neuroinflammation and intestinal inflammation in the attenuation of experimental autoimmune encephalomyelitis

N Dopkins, K Miranda, K Wilson, BL Holloman… - Journal of Neuroimmune …, 2021 - Springer
Cannabidiol (CBD) is a bioactive compound isolated from Cannabis plants that has
garnered attention within the medical community due to its potent anti-inflammatory …

Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models

PH Patra, M Barker‐Haliski, HS White, BJ Whalley… - …, 2019 - Wiley Online Library
Objective Epilepsy is a progressive neurological disease characterized by recurrent
seizures and behavioral comorbidities. We investigated the antiseizure effect of cannabidiol …

Biochemical aspects and therapeutic mechanisms of cannabidiol in epilepsy

APA Boleti, BEF Frihling, PS e Silva… - Neuroscience & …, 2022 - Elsevier
Epilepsy is a chronic neurological disease characterized by recurrent epileptic seizures.
Studies have shown the complexity of epileptogenesis and ictogenesis, in which …

Glial cells and their contribution to the mechanisms of action of cannabidiol in neuropsychiatric disorders

FF Scarante, MA Ribeiro, AF Almeida-Santos… - Frontiers in …, 2021 - frontiersin.org
Cannabidiol (CBD) is a phytocannabinoid with a broad-range of therapeutic potential in
several conditions, including neurological (epilepsy, neurodegenerative diseases, traumatic …

The anticonvulsant effects of cannabidiol in experimental models of epileptic seizures: From behavior and mechanisms to clinical insights

W Lazarini-Lopes, RA Do Val-da Silva… - Neuroscience & …, 2020 - Elsevier
Epilepsy is a neurological disorder characterized by the presence of seizures and
neuropsychiatric comorbidities. Despite the number of antiepileptic drugs, one-third of …

Oxytocin and Vasopressin Gene Expression in the Brain as Potential Biomarkers for Cannabidiol Therapeutic Efficacy

CM Frodella, SB Pruett, MK Ross, BLF Kaplan - Biomedicines, 2024 - mdpi.com
Over the last several years, there has been increased interest in cannabidiol (CBD) to treat
various ailments such as pain, anxiety, insomnia, and inflammation. The potential for CBD …

Immune responses regulated by cannabidiol

JM Nichols, BLF Kaplan - Cannabis and cannabinoid research, 2020 - liebertpub.com
Introduction: Cannabidiol (CBD) as Epidiolex®(GW Pharmaceuticals) was recently
approved by the US Food and Drug Administration (FDA) to treat rare forms of epilepsy in …