A large-scale multimodal CMOS biosensor array with 131,072 pixels and code-division multiplexed readout

K Hu, CE Arcadia, JK Rosenstein - IEEE Solid-State Circuits …, 2021 - ieeexplore.ieee.org
This letter presents a large-scale fully integrated multimodal sensor array for biological
imaging. The 512× 256 sensor array can perform spatially resolved electrochemical …

Field‐effect transistor‐based biosensor for pH sensing and mapping

H Ren, K Liang, D Li, Y Chen, Y Tang… - Advanced Sensor …, 2023 - Wiley Online Library
It is vital to acquire real‐time pH signals with high resolution as pH variation can reflect
important information regarding health status and physiological environment. Field‐effect …

Impact of technology scaling on ISFET performance for genetic sequencing

N Miscourides, P Georgiou - IEEE Sensors Journal, 2014 - ieeexplore.ieee.org
This paper investigates the impact of technology scaling according to Moore's law on the
performance of ion-sensitive field-effect transistors (ISFETs) as pH sensors for genetic …

Optimization of CMOS-ISFET-based biomolecular sensing: analysis and demonstration in DNA detection

G Xu, J Abbott, D Ham - IEEE Transactions on Electron Devices, 2016 - ieeexplore.ieee.org
Ion-sensitive field-effect transistors (ISFETs) have been used to detect a variety of
biomolecules whose charges alter the current or threshold voltage of the transistor. ISFETs …

A multi-modality CMOS sensor array for cell-based assay and drug screening

T Chi, JS Park, JC Butts, TA Hookway… - IEEE transactions on …, 2015 - ieeexplore.ieee.org
In this paper, we present a fully integrated multi-modality CMOS cellular sensor array with
four sensing modalities to characterize different cell physiological responses, including …

Enhanced biosensing resolution with foundry fabricated individually addressable dual-gated ISFETs

C Duarte-Guevara, FL Lai, CW Cheng… - Analytical …, 2014 - ACS Publications
The adaptation of semiconductor technologies for biological applications may lead to a new
era of inexpensive, sensitive, and portable diagnostics. At the core of these developing …

Ultrasensitive coplanar dual-gate ISFETs for point-of-care biomedical applications

JH Jeon, WJ Cho - ACS omega, 2020 - ACS Publications
The sensitivity of conventional ion-sensitive field-effect transistors (ISFETs) is limited by the
Nernst equation, which is not sufficient for detecting weak biological signals. In this study, we …

ISFET-based sensing and electric field actuation of DNA for on-chip detection: A review

L Keeble, N Moser, J Rodriguez-Manzano… - IEEE Sensors …, 2020 - ieeexplore.ieee.org
The advent of complementary metal-oxide-semiconductor (CMOS) based lab-on-chip (LoC)
technology, which combines on-chip sample handling with integrated sensing, heralds the …

Simultaneous DNA amplification and detection using a pH-sensing semiconductor system

C Toumazou, LM Shepherd, SC Reed, GI Chen… - Nature …, 2013 - nature.com
We developed an integrated chip for real-time amplification and detection of nucleic acid
using pH-sensing complementary metal-oxide semiconductor (CMOS) technology. Here we …

Multi-wire tri-gate silicon nanowires reaching milli-pH unit resolution in one micron square footprint

E Accastelli, P Scarbolo, T Ernst, P Palestri, L Selmi… - Biosensors, 2016 - mdpi.com
The signal-to-noise ratio of planar ISFET pH sensors deteriorates when reducing the area
occupied by the device, thus hampering the scalability of on-chip analytical systems which …