Clinical translation of scaffold-based bone tissue engineering (BTE) therapy still faces many
challenges despite intense investigations and advancement over the years. To address …

Bone tissue is a highly vascularized tissue and concomitant development of the vascular
system and mineralized matrix requires a synergistic interaction between osteogenesis and …

Vascularization of large bone grafts is one of the main challenges of bone tissue
engineering (BTE), and has held back the clinical translation of engineered bone constructs …

Bone tissue engineering (BTE) is a topic of interest for the last decade, and advances in
materials, processing techniques, and the understanding of bone healing pathways have …

Poor angiogenesis within tissue‐engineered grafts has been identified as a main challenge
limiting the clinical introduction of bone tissue‐engineering (BTE) approaches for the repair …

Reconstruction of critical-sized bone defects remains a tremendous challenge for surgeons
worldwide. Despite the variety of surgical techniques, current clinical strategies for bone …

Significant advances have been made in bone tissue engineering (TE) in the past decade.
However, classical bone TE strategies have been hampered mainly due to the lack of …

The management of bone defects is complicated by the presence of clinical conditions, such
as critical-sized defects created by high-energy trauma, tumour resection, infection, and …

Bone disorders are of significant concern due to increase in the median age of our
population. Traditionally, bone grafts have been used to restore damaged bone. Synthetic …

The management of large segmental bone defects caused by trauma or disease remains
clinically challenging within orthopaedics. The major impediment to bone healing with …