AURKA is a serine/threonine kinase overexpressed in several cancers. Originally identified
as a protein with multifaceted roles during mitosis, improvements in quantitative microscopy …

Aurora Kinase A (AURKA) is a positive regulator of mitosis with a strict cell cycle-dependent
expression pattern. Recently, novel oncogenic roles of AURKA have been uncovered that …

Many epithelial cancers show cell cycle dysfunction tightly correlated with the
overexpression of the serine/threonine kinase Aurora A (AURKA). Its role in mitotic …

Overexpression of the Aurora kinase A (AURKA) is oncogenic in many tumors. Many studies
of AURKA have focused on activities of this kinase in mitosis, and elucidated the …

Aurora kinase A (AURKA) is a conserved kinase that plays crucial roles in numerous cellular
processes. Although AURKA overexpression is frequent in human cancers, its pleiotropic …

Recent advances in high-throughput sequencing technologies and data science have
facilitated the development of precision medicine to treat cancer patients. Synthetic lethality …

Aurora kinase A (AURKA) belongs to the family of serine/threonine kinases, whose
activation is necessary for cell division processes via regulation of mitosis. AURKA shows …

Introduction: Based on its role as a mitotic regulatory kinase, overexpressed and associated
with aneuploidy in cancer, small-molecule inhibitors have been developed for Aurora-A …

Aurora kinases (AURKs) are serine/threonine protein kinases that play a critical role during
cell proliferation. Three isoforms of AURKs reported in mammals include AURKA, AURKB …

The centrosomal Aurora-A kinase (AURKA) regulates mitotic progression, and
overexpression and hyperactivation of AURKA commonly promotes genomic instability in …