ABSTRACT Type‐2 diabetes (T2D) is associated in observational studies with both higher
bone mineral density (BMD) and higher fracture risk for given BMD. These relationships may …

Aims/hypothesis Observational studies indicate that type 2 diabetes mellitus and fasting
glucose levels are associated with a greater risk for hip fracture, smaller bone area and …

We used two-sample Mendelian Randomization to reveal causal estimates of type 1
diabetes and bone. Type 1 diabetes was found to be a risk factor for bone metabolic health …

Preclinical studies demonstrated that bone plays a central role in energy metabolism.
However, how bone metabolism is related to the risk of diabetes in humans is unknown. We …

Background: Observational studies have demonstrated that increased bone mineral density
is associated with a higher risk of type 2 diabetes (T2D), but the relationship with risk of …

It remains unclear whether the relationship between type 2 diabetes mellitus (T2DM) and
bone mineral density (BMD) reflects causality in East Asian populations. Herein, a …

Exploring genetic pleiotropy can provide clues to a mechanism underlying the observed
epidemiological association between type 2 diabetes and heightened fracture risk. We …

The 'diabetic bone paradox'suggested that type 2 diabetes (T2D) patients would have higher
areal bone mineral density (BMD) but higher fracture risk than individuals without T2D. In …

Objective To reveal the relationship between Body Mass Index (BMI), type 2 diabetes, and
bone mineral density (BMD) using a mendelian randomization (MR) approach. Methods …

We performed a cross-sectional study using the National Health Examination and Nutrition
Survey (NHANES) data and a Mendelian randomisation (MR) study using the GWAS …