[HTML][HTML] Alterations in metabolome and microbiome: new clues on cathelicidin-related antimicrobial peptide alleviates acute ulcerative colitis

N Jiang, Z Liu, H Wang, L Zhang, M Li, G Li… - Frontiers in …, 2024 - frontiersin.org
Ulcerative colitis (UC) is a chronic and recurrent inflammatory disease of the gastrointestinal
tract. This study aimed to determine the effect of cathelicidin-related antimicrobial peptide …

[HTML][HTML] Alterations in metabolome and microbiome signatures provide clues to the role of antimicrobial peptide KT2 in ulcerative colitis

Q Nan, Y Ye, Y Tao, X Jiang, Y Miao, J Jia… - Frontiers in …, 2023 - frontiersin.org
Introduction Ulcerative colitis (UC) is an inflammatory disease of the intestinal tract with
unknown etiology. Both genetic and environmental factors are involved in the occurrence …

Heterophyllin B an active cyclopeptide alleviates dextran sulfate sodium‐induced colitis by modulating gut microbiota and repairing intestinal mucosal barrier via …

C Chen, H Liang, J Wang, G Ren, R Li… - Molecular Nutrition & …, 2022 - Wiley Online Library
Scope Advances in pathology broaden the perception of the intimate interaction between
gut microbiota dysbiosis and the pathogenesis of ulcerative colitis (UC), but the potential …

Profiling of polar metabolites in mouse feces using four analytical platforms to study the effects of cathelicidin-related antimicrobial peptide in alcoholic liver disease

L He, F Li, X Yin, P Bohman, S Kim… - Journal of proteome …, 2019 - ACS Publications
Alterations in gut bacterial homeostasis result in changes in intestinal metabolites. To
investigate the effects of alcohol on fecal metabolites and the role of cathelicidin-related …

[HTML][HTML] Cecropin A alleviates inflammation through modulating the gut microbiota of C57BL/6 mice with DSS-induced IBD

Z Zhai, F Zhang, R Cao, X Ni, Z Xin, J Deng… - Frontiers in …, 2019 - frontiersin.org
The present study is undertaken to assess the alleviating effects of antimicrobial peptide
cecropin A on inflammatory bowel disease (IBD) in C57BL/6 mice and changes in the gut …

Beneficial effects of celastrol on immune balance by modulating gut microbiota in experimental ulcerative colitis mice

M Li, W Guo, Y Dong, W Wang, C Tian… - Genomics …, 2022 - academic.oup.com
Ulcerative colitis (UC) is a chronic inflammatory bowel disease caused by many factors
including colonic inflammation and microbiota dysbiosis. Previous studies have indicated …

Synergistic effect of berberine hydrochloride and dehydrocostus lactone in the treatment of ulcerative colitis: Take gut microbiota as the target

C Xu, L Zhao, W Zhou, Y Li, H Hu, Z Wang - International …, 2023 - Elsevier
Ulcerative colitis (UC) is a difficult-to-cure and recurrent inflammatory bowel disease, and it
is difficult to maintain long-term results with a single drug. Inspired by clinical medication in …

[HTML][HTML] Recombinant CRAMP-producing Lactococcus lactis attenuates dextran sulfate sodium-induced colitis by colonic colonization and inhibiting p38/NF-κB …

J Li, S Yu, X Pan, M Zhang, Z Lv, LL Pan… - Food & Nutrition …, 2021 - ncbi.nlm.nih.gov
Background Inflammatory bowel diseases (IBDs) are generally characterized by persistent
abdominal pain and diarrhea caused by chronic inflammation in the intestine. Cathelicidins …

[HTML][HTML] Gut microbiota and related metabolites were disturbed in ulcerative colitis and partly restored after mesalamine treatment

L Dai, Y Tang, W Zhou, Y Dang, Q Sun… - Frontiers in …, 2021 - frontiersin.org
Mesalamine has been well used in the improvement of ulcerative colitis (UC) in clinics,
however, the underlying mechanisms were not well illustrated. To explore its efficacy from …

[HTML][HTML] Arecoline aggravates acute ulcerative colitis in mice by affecting intestinal microbiota and serum metabolites

H Zhao, T Ding, Y Chen, W Yang, J Rao… - Frontiers in …, 2023 - frontiersin.org
Arecoline is an alkaloid extracted from betel nut, which has various pharmacological effects.
In the present study, we showed that arecoline aggravated experimental acute ulcerative …