S100B Secretion in Astrocytes, Unlike C6 Glioma Cells, Is Downregulated by Lactate

NG Selistre, L Rodrigues, BC Federhen, V Gayger-Dias… - Metabolites, 2023 - mdpi.com
S100B is a calcium-binding protein produced and secreted by astrocytes in response to
various extracellular stimuli. C6 glioma cells are a lineage commonly employed for astroglial …

Astroglial S100B Secretion Is Mediated by Ca2+ Mobilization from Endoplasmic Reticulum: A Study Using Forskolin and DMSO as Secretagogues

MC Leite, F Galland, MC Guerra, L Rodrigues… - International Journal of …, 2023 - mdpi.com
S100B, a homodimeric Ca2+-binding protein, is produced and secreted by astrocytes, and
its extracellular levels have been used as a glial marker in brain damage and …

S100B Secretion in Acute Brain Slices: Modulation by Extracellular Levels of Ca2+ and K+

P Nardin, L Tortorelli, A Quincozes-Santos… - Neurochemical …, 2009 - Springer
Hippocampal slices have been widely used to investigate electrophysiological and
metabolic neuronal parameters, as well as parameters of astroglial activity including protein …

S100B content and secretion decrease in astrocytes cultured in high-glucose medium

P Nardin, F Tramontina, MC Leite… - Neurochemistry …, 2007 - Elsevier
S100B is an astrocyte calcium-binding protein that plays a regulatory role in the cytoskeleton
and cell cycle. Moreover, extracellular S100B, a marker of glial activation in several …

High glutamate decreases S100B secretion by a mechanism dependent on the glutamate transporter

F Tramontina, MC Leite, D Gonçalves… - Neurochemical …, 2006 - Springer
Several molecules have been shown to be involved in glial-neuronal communication,
including S100B, an astrocyte-derived neurotrophic cytokine. Extracellular S100B protects …

S100B is expressed in, and released from, OLN-93 oligodendrocytes: influence of serum and glucose deprivation

J Steiner, HG Bernstein, B Bogerts, T Gos… - Neuroscience, 2008 - Elsevier
S100B (member of a family of proteins that are 100% soluble in ammonium sulfate at neutral
pH) has been widely used as astrocyte marker in animal models and in human brain …

Insulin stimulates S100B secretion and these proteins antagonistically modulate brain glucose metabolism

KM Wartchow, AC Tramontina, DF de Souza… - Neurochemical …, 2016 - Springer
Brain metabolism is highly dependent on glucose, which is derived from the blood
circulation and metabolized by the astrocytes and other neural cells via several pathways …

High glutamate decreases S100B secretion stimulated by serum deprivation in astrocytes

D Gonçalves, J Karl, M Leite, L Rotta, C Salbego… - …, 2002 - journals.lww.com
S100B is a calcium-binding protein expressed and secreted by astrocytes, playing a
neurotrophic role in neighboring cells. A protective role of the S100B against glutamate …

S100B actions on glial and neuronal cells in the developing brain: An overview

K Hernández-Ortega, AA Canul-Euan… - Frontiers in …, 2024 - frontiersin.org
The S100B is a member of the S100 family of “E” helix–loop-“F” helix structure (EF) hand
calcium-binding proteins expressed in diverse glial, selected neuronal, and various …

S100B expression in and effects on microglia

C Adami, G Sorci, E Blasi, AL Agneletti, F Bistoni… - Glia, 2001 - Wiley Online Library
We evaluated the intracellular and extracellular biological role of S100B protein with respect
to microglia. S100B, which belongs to the multigenic family of Ca2+‐binding proteins, is …