Purpose: Other cDNA microarray studies have shown that hepsin is one of the highly over
expressed genes in prostate cancer tissue compared with nonmalignant and benign …

[Frontiers in Bioscience 12, 5052-5059, September 1, 2007] 5052 Hepsin and prostate cancer
Qingyu Wu1, Gordon Parry2 1Department Page 1 [Frontiers in Bioscience 12, 5052-5059 …

Prostate cancer is the most commonly diagnosed noncutaneous cancer in men. Despite this
fact, many of the genetic changes that coincide with prostate cancer progression remain …

Expression of HEPSIN, a type II transmembrane serine protease in prostate cancer (CaP),
has been highlighted by several studies analyzing CaP-specific gene expression alterations …

Objective Although many studies have documented the tumor-promoting role of hepsin in
several types of malignancies, little is known about its clinical and biological significance in …

Hepsin is a type II transmembrane serine protease that is expressed in normal liver, and at
lower levels in kidney, pancreas, and testis. Several studies have shown that hepsin mRNA …

BACKGROUND Hepsin is a cell surface protease that is over‐expressed in more than 90%
of human prostate cancer cases. The previously developed Probasin‐hepsin/Large …

The majority of cancer-related deaths are associated with metastasis; however, little is
known about the mechanisms of this process. Hepsin is a cell surface serine protease that is …

PURPOSE: Recent studies have shown that hepsin, a serine protease, is over expressed in
prostate cancers, implicating hepsin activity in tumor invasion. Using microarray technology …

Cell surface proteolysis is important for the generation of bioactive proteins mediating tumor
progression. Recent studies suggest that the membrane‐anchored cell surface proteinases …