Among the four proteolytic systems in the cell, autophagy and the ubiquitin-proteasome
system (UPS) are the main proteolytic events that allow for the removal of cell debris and …

Skeletal muscles are considered the largest reservoirs of the protein pool in the body and
are critical for the maintenances of body homeostasis. Skeletal muscle atrophy is supported …

Skeletal muscle is one of the most abundant and highly plastic tissues. The ubiquitin–
proteasome system (UPS) is recognised as a major intracellular protein degradation system …

Muscle atrophy complicates many diseases as well as aging, and its presence predicts both
decreased quality of life and survival. Much work has been conducted to define the …

Skeletal muscle adapts its mass as consequence of physical activity, metabolism and
hormones. Catabolic conditions or inactivity induce signaling pathways that regulate the …

A number of recent studies have highlighted the importance of autophagy and the ubiquitin-
proteasome in the pathogenesis of muscle wasting in different types of inherited muscle …

Skeletal muscles underpin myriad human activities, maintaining an intricate balance
between protein synthesis and degradation crucial to muscle mass preservation …

Muscle mass represents 40–50% of the human body and, in mammals, is one of the most
important sites for the control of metabolism. Moreover, during catabolic conditions, muscle …

Aging is a complex phenomenon that has detrimental effects on tissue homeostasis. The
skeletal muscle is one of the earliest tissues to be affected and to manifest age-related …

The skeletal muscle plays an important role in maintaining whole‐body mechanics,
metabolic homeostasis, and interorgan crosstalk. However, during aging, functional and …