Background Nanopore metagenomics has been used for infectious disease diagnosis for
bacterial pathogens. However, this technology currently lacks comprehensive performance …

Objectives Lower respiratory tract infections (LRTIs) are one of the causes of mortality
among infectious diseases. Microbial cultures commonly used in clinical practice are time …

Background Diversified etiology of lower respiratory tract infection renders diagnosis
challenging. The mainstay microbial culture is time-consuming and constrained by variable …

Respiratory tract infection (RTI) remains a significant cause of morbidity and mortality across
the globe. The optimal management of RTI relies upon timely pathogen identification via …

Lower respiratory infections (LRIs) accounted for three million deaths worldwide in 2016, the
leading infectious cause of mortality. The “gold standard” for investigation of bacterial LRIs is …

Background Next-generation sequencing of the metagenome (mNGS) is increasingly used
in pathogen diagnosis for infectious diseases due to its short detection time. The time for …

This review provides an in-depth discussion of the development, principles and utility of
nanopore sequencing technology and its diverse applications in the identification of various …

Objective To evaluate the value of nanopore targeted sequencing in diagnosing pneumonia
pathogens. Methods This large-scale multicentre prospective study performed in 8 hospitals …

The gold standard for clinical diagnosis of bacterial lower respiratory infections (LRIs) is
culture, which has poor sensitivity and is too slow to guide early, targeted antimicrobial …

Metagenomic sequencing analysis has been implemented as an alternative approach for
pathogen diagnosis in recent years, which is independent on cultivation and able to identify …