Histone posttranslational modifications represent a versatile set of epigenetic marks
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …

Cancer is a disease of genome sequence alterations as well as epigenetic changes.
Epigenetics refers in part to the mechanisms by which histones affect various DNA-based …

It is now widely recognized that epigenetic events are important mechanisms underlying
cancer development and progression. Epigenetic information in chromatin includes covalent …

Oncogenesis is a multistep process mediated by a variety of factors including epigenetic
modifications. Global epigenetic post-translational modifications have been detected in …

Epigenetic dysregulation is being increasingly recognized as a hallmark of cancer. Post-
translational modifications of histones, in particular, are known to play important roles gene …

Post-translational modification of histones provides an important regulatory platform for
processes such as gene expression, DNA replication and repair, chromosome condensation …

Posttranslational modifications to histones affect chromatin structure and function resulting in
altered gene expression and changes in cell behavior. Aberrant gene expression and …

Cancer is one of the most common human diseases. It is long known that mutations in key
regulator genes are hallmarks of all cancer types. Apart from these classical genetic …

Histone modifications are key factors in chromatin packaging, and are responsible for gene
regulation during cell fate determination and development. Abnormal alterations in histone …

Global alterations in epigenetic landscape are now recognized as a hallmark of cancer.
Epigenetic mechanisms such as DNA methylation, histone modifications, nucleosome …