Plasma cell-free DNA (cfDNA) is derived from cellular death in various tissues. Investigating
the origin of cfDNA through tissue/cell type deconvolution allows us to detect changes in …

Plasma cell-free DNA (cfDNA) is a noninvasive biomarker for cell death of all organs.
Deciphering the tissue origin of cfDNA can reveal abnormal cell death because of diseases …

Circulating cell-free DNA (cfDNA) fragments have characteristics that are specific to the cell
types that release them. Current methods for cfDNA deconvolution typically use disease …

Circulating cell-free DNA (cfDNA) in the bloodstream originates from dying cells and is a
promising noninvasive biomarker for cell death. Here, we propose an algorithm, CelFiE, to …

Plasma cell-free DNA (cfDNA) are small molecules generated through a non-random
fragmentation procedure. Despite commendable translational values in cancer liquid biopsy …

Cell-free DNA (cfDNA) are DNA fragments originating from dying cells that are detectable in
bodily fluids, such as the plasma. Accelerated cell death, for example caused by disease …

Reference methylomes, used in deconvolution algorithms to determine cell-free DNA tissue
sources, were based on driver CpGs from either microarray or sequencing platforms. Cross …

Methylation patterns of circulating cell-free DNA (cfDNA) contain rich information about
recent cell death events in the body. Here, we present an approach for unbiased …

Circulating cell-free DNA (cfDNA) is a promising biomarker for the diagnosis and prognosis
of many diseases, including cancer. The genome-wide non-random fragmentation patterns …

Multimodal epigenetic characterization of cell-free DNA (cfDNA) could improve the
performance of blood-based early cancer detection. However, integrative profiling of cfDNA …