Since hyperactivity of the protein kinase DYRK1A is linked to several neurodegenerative
disorders, DYRK1A inhibitors have been suggested as potential therapeutics for Down …

Alzheimer, the fourth leading cause of death embodies a key responsible event including
formation of β-amyloid protein clustering to amyloid plaque on blood vessels. The origin of …

With 24.3 million people affected in 2005 and an estimated rise to 42.3 million in 2020,
dementia is currently a leading unmet medical need and costly burden on public health …

The protein kinase Dyrk1A modulates several processes relevant to the development or
progression of Alzheimer's disease (AD), eg through phosphorylation of tau protein, amyloid …

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) is a potential target
in Alzheimer's disease (AD) because of the established correlation between its over …

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a potential drug
target because of its role in the development of Down syndrome and Alzheimer's disease …

Background: Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most
common form of dementia, especially in the elderly. Due to the increase in life expectancy, in …

The protein kinase DYRK1A has been suggested to act as one of the intracellular regulators
contributing to neurological alterations found in individuals with Down syndrome. For an …

In total, 47,500,000 people worldwide are affected by dementia and this number is estimated
to double by 2030 and triple within 2050 resulting in a huge burden on public health …

Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a conserved
protein kinase that plays essential roles in various biological processes. It is located in the …