Schizophrenia alters basic brain processes of perception, emotion, and judgment to cause
hallucinations, delusions, thought disorder, and cognitive deficits. Unlike neurodegeneration …

Schizophrenia is a severe neuropsychiatric syndrome with psychotic behavioral
abnormalities and marked cognitive deficits. It is widely accepted that genetic and …

Many structural alterations occur in the brain in schizophrenia (see Harrison 1999, Shapiro
1993), and the prevailing hypothesis is that these are caused by an anomaly in brain …

Schizophrenia is associated with alterations in sensory, motor, and cognitive functions that
emerge before psychosis onset; identifying pathogenic processes that can account for this …

Large-scale genomic studies of schizophrenia have identified hundreds of genetic loci
conferring risk to the disorder. This progress offers an important route toward defining the …

Patients with schizophrenia experience cognitive dysfunction and negative symptoms that
do not respond to current drug treatments. Historical evidence is consistent with the …

Recent large-scale genomic studies have revealed two broad classes of risk alleles for
schizophrenia: a polygenic component of risk mediated through multiple common risk …

The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …

The pathological mechanisms underlying schizophrenia are unclear. Although genetic
susceptibility factors for schizophrenia likely influence neurodevelopmental processes, the …

Schizophrenia (SZ) is often described as a disease of neuronal connectivity. Cognitive
processes such as working memory, which are particularly dependent on the proper …