The well‐stirred hepatic clearance model (WSHM) has been expanded to include drug
transporters (ie, extended clearance model [ECM]). However, the consequences of this …

Due to its implications for both dose level and frequency, clearance rate is one of the most
important pharmacokinetic parameters to consider in the design of drug candidates …

Drug metabolism in pharmaceutical research has traditionally focused on the well-defined
aspects of absorption, distribution, metabolism and excretion, commonly-referred to ADME …

Hepatobiliary transport mechanisms have been identified to play a significant role in
determining the systemic clearance for a number of widely prescribed drugs and an …

Quantitative prediction of the in vivo drug–drug interactions (DDIs) caused by metabolic
inhibition, one of the most common DDI mechanisms in clinical practice, has long been …

Transporters play an important role in drug absorption, disposition, and drug action. The
evaluation of drug transporters requires a comprehensive understanding of transporter …

The greater utilization and acceptance of physiologically‐based pharmacokinetic (PBPK)
modeling to evaluate the potential metabolic drug–drug interactions is evident by the …

Efflux transport systems are essential to suppress the absorption of xenobiotics from the
intestinal lumen and protect the critical tissues at the blood-tissue barriers, such as the blood …

▪ Abstract It is of great importance to predict in vivo pharmacokinetics in humans based on in
vitro data. We summarize recent findings of the quantitative prediction of the hepatic …

It is considered that an increased understanding of drug transport in the intestine, liver,
kidney and blood–brain barrier is vital to the successful development of new and effective …