Background and Aims Hepatic sinusoidal cells are known actors in the fibrogenic response
to injury. Activated hepatic stellate cells (HSCs), liver sinusoidal endothelial cells, and …

Iterative liver injury results in progressive fibrosis disrupting hepatic architecture,
regeneration potential, and liver function. Hepatic stellate cells (HSCs) are a major source of …

Background & Aims: Liver fibrosis is a pathological healing process resulting from hepatic
stellate cell (HSC) activation and the generation of myofibroblasts from activated HSCs. The …

Liver microcirculation plays an essential role in the progression and aggravation of chronic
liver disease. Hepatic sinusoid environment, mainly composed by hepatocytes, liver …

Background and Aims HSCs and portal fibroblasts (PFs) are the major sources of collagen‐
producing myofibroblasts during liver fibrosis, depending on different etiologies. However …

Background Dysfunction of liver sinusoidal endothelial cells (LSECs) is permissive for the
progression of liver fibrosis and cirrhosis and responsible for its clinical complications. Here …

Non-alcoholic steatohepatitis (NASH) signified by hepatic steatosis, inflammation,
hepatocellular injury, and fibrosis is a growing cause of chronic liver disease, cirrhosis, and …

Chronic liver injury can be caused by many factors, including virus infection, alcohol intake,
cholestasis and abnormal fat accumulation. Nonalcoholic steatohepatitis (NASH) has …

Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. It is a critical pre-stage condition of severe hepatopathy, characterized by excessive …

Advanced hepatic fibrosis, driven by the activation of hepatic stellate cells (HSCs), affects
millions worldwide and is the strongest predictor of mortality in nonalcoholic steatohepatitis …