The repair of bone defects caused by trauma, infection or tumor resection is a major clinical
orthopedic challenge. The application of bone grafts in orthopedic procedures is associated …

In vitro vascularization is an upcoming strategy to solve the problem of insufficient blood
supply after implantation. Although recent publications show promising results, these studies …

Tissue engineering provides unique opportunities for regenerating diseased or damaged
tissues using cells obtained from tissue biopsies. Tissue engineered grafts can also be used …

Background Improved understanding of the interactions between bone cells and endothelial
cells involved in osteogenesis should aid the development of new strategies for bone tissue …

To engineer tissues with clinically relevant dimensions, one must overcome the challenge of
rapidly creating functional blood vessels to supply cells with oxygen and nutrients and to …

One of the major problems with bone tissue engineering is the development of a rapid
vascularization after implantation to supply the growing osteoblast cells with the nutrients to …

Angiogenesis is a key element in early wound healing and is considered important for tissue
regeneration and for directing inflammatory cells to the wound site. The improvement of …

There have been extensive research efforts to develop new strategies for bone tissue
engineering. These have mainly focused on vascularization during the development and …

Osteogenesis occurs in striking interaction with angiogenesis. There is growing evidence
that endothelial cells are involved in the modulation of osteoblast differentiation. We …

Bone development and remodeling depend on complex interactions between bone-forming
osteoblasts and other cells present within the bone microenvironment, particularly …