Identification of prognostic genes in uveal melanoma microenvironment

H Luo, C Ma - PLoS One, 2020 - journals.plos.org
Background Uveal melanoma (UM) is the most common primary intraocular malignancy in
adults. Many previous studies have demonstrated that the infiltrating of immune and stromal …

Prognostic implications of novel ten-gene signature in uveal melanoma

H Luo, C Ma, J Shao, J Cao - Frontiers in Oncology, 2020 - frontiersin.org
Background: Uveal melanoma (UM) is the most common primary intraocular cancer in
adults. Genomic studies have provided insights into molecular subgroups and oncogenic …

Identification of co-expressed gene networks promoting CD8+ T cell infiltration and having prognostic value in uveal melanoma

C Zhang, J Xiao, L Fa, F Jiang, H Jiang, L Zhou… - BMC …, 2023 - Springer
Current immunotherapies are unsatisfactory against uveal melanoma (UM); however,
elevated CD8+ T cell infiltration level indicates poor prognosis in UM. Here, we aimed to …

Integrated single-cell and transcriptome sequencing analyses develops a metastasis-based risk score system for prognosis and immunotherapy response in uveal …

S Meng, T Zhu, Z Fan, Y Cheng, Y Dong… - Frontiers in …, 2023 - frontiersin.org
Background: Uveal melanoma (UM) is the most frequent ocular neoplasm with a strong
metastatic ability. The prognostic value of metastasis-associated genes (MAGs) of UM …

Identification of a novel immune-related gene signature for prognosis and the tumor microenvironment in patients with uveal melanoma combining single-cell and bulk …

W Wang, H Zhao, S Wang - Frontiers in Immunology, 2023 - frontiersin.org
Introduction Uveal melanoma (UVM) is the most invasive intraocular malignancy in adults
with a poor prognosis. Growing evidence revealed that immune-related gene is related to …

Machine learning and single-cell RNA sequencing reveal relationship between intratumor CD8+ T cells and uveal melanoma metastasis

S Chen, Z Tang, Q Wan, W Huang, X Li, X Huang… - Cancer Cell …, 2024 - Springer
Purpose Uveal melanoma (UM) is adults' most common primary intraocular malignant tumor.
It has been observed that 40% of patients experience distant metastasis during subsequent …

Integrated analyses identify potential prognostic markers for uveal melanoma

Y Ni, Z Zhang, G Chen, W Long, L Tong… - Experimental Eye …, 2019 - Elsevier
Uveal melanoma (UM) is the most common primary intraocular malignant tumor in adults,
which has a high rate of metastases and can induce vision loss and even death to the …

The prognostic landscape of adaptive immune resistance signatures and infiltrating immune cells in the tumor microenvironment of uveal melanoma

Y Wang, Y Xu, X Dai, X Lin, Y Shan, J Ye - Experimental eye research, 2020 - Elsevier
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults and
has a high mortality rate. Tumor microenvironment (TME) is crucial in controlling and …

Additive role of immune system infiltration and angiogenesis in uveal melanoma progression

S García-Mulero, MH Alonso, LP Del Carpio… - International journal of …, 2021 - mdpi.com
Uveal melanoma (UM) is a malignant tumor that arises in the melanocytes of the uveal tract.
It is the most frequent eye cancer, and despite new therapeutic approaches, prognosis is still …

Identification of differentially expressed genes and functional annotations associated with metastases of the uveal melanoma

Y Xu, W Han, WH Xu, Y Wang, XL Yang… - Journal of cellular …, 2019 - Wiley Online Library
Uveal melanoma (UVM) is an adult intraocular malignancy which is the most frequent and
has a high tendency for metastasis. This study aims to develop significant differential gene …